methyl 2-(3,4-dimethoxyphenyl)-4-formyl-7-methoxybenzo[b]furan-3-carboxylate

Base Information

• Chemical Name: methyl 2-(3,4-dimethoxyphenyl)-4-formyl-7-methoxybenzo[b]furan-3-carboxylate
• CAS No.: 1385815-70-2
• Molecular Formula: C₂₀H₁₈O₇
• Molecular Weight: 370.359
• Mol file: 1385815-70-2.mol

Synonyms:methyl 2-(3,4-dimethoxyphenyl)-4-formyl-7-methoxybenzo[b]furan-3-carboxylate

Chemical Property of methyl 2-(3,4-dimethoxyphenyl)-4-formyl-7-methoxybenzo[b]furan-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-(3,4-dimethoxyphenyl)-4-formyl-7-methoxybenzo[b]furan-3-carboxylate

There total 1 articles about methyl 2-(3,4-dimethoxyphenyl)-4-formyl-7-methoxybenzo[b]furan-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

(3,4-dimethoxyphenyl)propynoic acid methyl ester (62497-24-9) + 2-iodoisovanillin (138490-94-5) → methyl 2-(3,4-dimethoxyphenyl)-4-formyl-7-methoxybenzo[b]furan-3-carboxylate (1385815-70-2)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; sodium hydrogencarbonate; lithium chloride; In N,N-dimethyl-formamide; at 110 ℃; for 6h; Inert atmosphere;

DOI:10.1039/c2ob25575h

Reference yield: 90.0%

methyl 2-(3,4-dimethoxyphenyl)-4-formyl-7-methoxybenzo[b]furan-3-carboxylate (1385815-70-2) → methyl 4-hydroxymethyl-7-methoxy-2-(3,4-dimethoxyphenyl)-benzo[b]furan-3-carboxylate (1385815-76-8)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 3h; Inert atmosphere;

DOI:10.1039/c2ob25575h

Reference yield: 85.0%

methyl 2-(3,4-dimethoxyphenyl)-4-formyl-7-methoxybenzo[b]furan-3-carboxylate (1385815-70-2) → methyl 4-methyl-7-methoxy-2-(3,4-dimethoxyphenyl)benzo[b]furan-3-carboxylate (1385815-78-0)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1039/c2ob25575h

upstream raw materials:

(3,4-dimethoxyphenyl)propynoic acid methyl ester

2-iodoisovanillin

Downstream raw materials:

(2S,3S)-methyl 2-(3,4-dimethoxyphenyl)-4-((E)-3-(((R)-3-(3,4-dimethoxyphenyl)-1-methoxy-1-oxopropan-2-yl)oxy)-3-oxoprop-1-en-1-yl)-7-methoxy-2,3-dihydrobenzofuran-3-carboxylate

(2R,3R)-methyl 2-(3,4-dimethoxyphenyl)-4-((E)-3-(((R)-3-(3,4-dimethoxyphenyl)-1-methoxy-1-oxopropan-2-yl)oxy)-3-oxoprop-1-en-1-yl)-7-methoxy-2,3-dihydrobenzofuran-3-carboxylate

methyl 4-hydroxymethyl-7-methoxy-2-(3,4-dimethoxyphenyl)-benzo[b]furan-3-carboxylate

methyl 4-methyl-7-methoxy-2-(3,4-dimethoxyphenyl)benzo[b]furan-3-carboxylate