methyl 4-hydroxymethyl-7-methoxy-2-(3,4-dimethoxyphenyl)-benzo[b]furan-3-carboxylate

Base Information

Chemical Name:methyl 4-hydroxymethyl-7-methoxy-2-(3,4-dimethoxyphenyl)-benzo[b]furan-3-carboxylate
CAS No.:1385815-76-8
Molecular Formula:C₂₀H₂₀O₇
Molecular Weight:372.375
Hs Code.:

Synonyms:methyl 4-hydroxymethyl-7-methoxy-2-(3,4-dimethoxyphenyl)-benzo[b]furan-3-carboxylate

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Chemical Property of methyl 4-hydroxymethyl-7-methoxy-2-(3,4-dimethoxyphenyl)-benzo[b]furan-3-carboxylate

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Technology Process of methyl 4-hydroxymethyl-7-methoxy-2-(3,4-dimethoxyphenyl)-benzo[b]furan-3-carboxylate

There total 3 articles about methyl 4-hydroxymethyl-7-methoxy-2-(3,4-dimethoxyphenyl)-benzo[b]furan-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1385815-70-2
methyl 2-(3,4-dimethoxyphenyl)-4-formyl-7-methoxybenzo[b]furan-3-carboxylate

: 1385815-76-8
methyl 4-hydroxymethyl-7-methoxy-2-(3,4-dimethoxyphenyl)-benzo[b]furan-3-carboxylate

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.1039/c2ob25575h

Reference yield:

: 62497-24-9
(3,4-dimethoxyphenyl)propynoic acid methyl ester

: 1385815-76-8
methyl 4-hydroxymethyl-7-methoxy-2-(3,4-dimethoxyphenyl)-benzo[b]furan-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: bis-triphenylphosphine-palladium(II) chloride; sodium hydrogencarbonate; lithium chloride / N,N-dimethyl-formamide / 6 h / 110 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / methanol / 3 h / 20 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; palladium 10% on activated carbon; hydrogen; sodium hydrogencarbonate; lithium chloride; In methanol; N,N-dimethyl-formamide;
DOI:10.1039/c2ob25575h

Reference yield:

: 138490-94-5
2-iodoisovanillin

: 1385815-76-8
methyl 4-hydroxymethyl-7-methoxy-2-(3,4-dimethoxyphenyl)-benzo[b]furan-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: bis-triphenylphosphine-palladium(II) chloride; sodium hydrogencarbonate; lithium chloride / N,N-dimethyl-formamide / 6 h / 110 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / methanol / 3 h / 20 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; palladium 10% on activated carbon; hydrogen; sodium hydrogencarbonate; lithium chloride; In methanol; N,N-dimethyl-formamide;
DOI:10.1039/c2ob25575h