(3R,4S,5S)-5-Benzyloxycarbonylamino-3-hydroxy-2,2-dimethyl-4-phenylselanyl-hexanoic acid methyl ester

Base Information

Chemical Name:(3R,4S,5S)-5-Benzyloxycarbonylamino-3-hydroxy-2,2-dimethyl-4-phenylselanyl-hexanoic acid methyl ester
CAS No.:177274-52-1
Molecular Formula:C₂₃H₂₉NO₅Se
Molecular Weight:478.447
Hs Code.:

Synonyms:(3R,4S,5S)-5-Benzyloxycarbonylamino-3-hydroxy-2,2-dimethyl-4-phenylselanyl-hexanoic acid methyl ester

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Chemical Property of (3R,4S,5S)-5-Benzyloxycarbonylamino-3-hydroxy-2,2-dimethyl-4-phenylselanyl-hexanoic acid methyl ester

Chemical Property:

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Technology Process of (3R,4S,5S)-5-Benzyloxycarbonylamino-3-hydroxy-2,2-dimethyl-4-phenylselanyl-hexanoic acid methyl ester

There total 5 articles about (3R,4S,5S)-5-Benzyloxycarbonylamino-3-hydroxy-2,2-dimethyl-4-phenylselanyl-hexanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 31469-15-5
1-methoxy-2-methyl-1-trimethylsiloxy-1-propene

: ((S)-1-Methyl-3-oxo-2-phenylselanyl-propyl)-carbamic acid benzyl ester

: 177274-52-1
(3R,4S,5S)-5-Benzyloxycarbonylamino-3-hydroxy-2,2-dimethyl-4-phenylselanyl-hexanoic acid methyl ester

Guidance literature:: With boron trifluoride diethyl etherate; In dichloromethane; at -78 ℃;
DOI:10.1016/0040-4039(96)00352-8

Reference yield:

: 1142-20-7
N-Cbz-Ala

: 177274-52-1
(3R,4S,5S)-5-Benzyloxycarbonylamino-3-hydroxy-2,2-dimethyl-4-phenylselanyl-hexanoic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: acetyl chloride

2: DIBALH, / toluene / -78 °C

3: NaHMDS / tetrahydrofuran

4: 65 percent / CH₂Cl₂ / -78 °C

5: 40 percent / BF₃*OEt₂ / CH₂Cl₂ / -78 °C

With boron trifluoride diethyl etherate; sodium hexamethyldisilazane; diisobutylaluminium hydride; acetyl chloride; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1016/0040-4039(96)00352-8

Reference yield:

: 28819-05-8
(S)-2-benzyloxycarbonylamino-propionic acid methyl ester

: 177274-52-1
(3R,4S,5S)-5-Benzyloxycarbonylamino-3-hydroxy-2,2-dimethyl-4-phenylselanyl-hexanoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: DIBALH, / toluene / -78 °C

2: NaHMDS / tetrahydrofuran

3: 65 percent / CH₂Cl₂ / -78 °C

4: 40 percent / BF₃*OEt₂ / CH₂Cl₂ / -78 °C

With boron trifluoride diethyl etherate; sodium hexamethyldisilazane; diisobutylaluminium hydride; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1016/0040-4039(96)00352-8