Technology Process of 9-benzyl-4-hydroxy-β-carboline
There total 6 articles about 9-benzyl-4-hydroxy-β-carboline which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
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Multi-step reaction with 7 steps
1: 99 percent / LiAlH4 / tetrahydrofuran / 0.5 h / Ambient temperature
2: 96 percent / MnO2 / CH2Cl2 / 6 h / Ambient temperature
3: 79 percent / triethylamine, NaBH3CN / ethanol / 14 h / Ambient temperature
4: 99 percent / ethyl formate / 20 h / Ambient temperature
5: 94 percent / methanesulfonic acid / 1 h / 70 °C / other reagent: polyphosphoric acid
6: 96 percent / HCl / dioxane / 0.5 h / Heating
7: 100 percent / palladium on charcoal / decahydronaphthalene / 7.5 h / 200 °C
With
hydrogenchloride; manganese(IV) oxide; lithium aluminium tetrahydride; methanesulfonic acid; sodium cyanoborohydride; triethylamine; formic acid ethyl ester;
palladium on activated charcoal;
In
tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; decalin;
DOI:10.1016/S0040-4020(96)01112-X
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 79 percent / triethylamine, NaBH3CN / ethanol / 14 h / Ambient temperature
2: 99 percent / ethyl formate / 20 h / Ambient temperature
3: 94 percent / methanesulfonic acid / 1 h / 70 °C / other reagent: polyphosphoric acid
4: 96 percent / HCl / dioxane / 0.5 h / Heating
5: 100 percent / palladium on charcoal / decahydronaphthalene / 7.5 h / 200 °C
With
hydrogenchloride; methanesulfonic acid; sodium cyanoborohydride; triethylamine; formic acid ethyl ester;
palladium on activated charcoal;
In
1,4-dioxane; ethanol; decalin;
DOI:10.1016/S0040-4020(96)01112-X
