4-Methoxy-1-methoxycarbonyl-beta-carboline

Base Information

• Chemical Name: 4-Methoxy-1-methoxycarbonyl-beta-carboline
• CAS No.: 60807-25-2
• Molecular Formula: C14H12N2O3
• Molecular Weight: 256.256680
• Hs Code.: 2933990090
• Mol file: 60807-25-2.mol

Synonyms:W1176;

Chemical Property of 4-Methoxy-1-methoxycarbonyl-beta-carboline

Chemical Property:

• Vapor Pressure: 1.74E-10mmHg at 25°C
• Refractive Index: 1.688
• Boiling Point: 509.1 °C at 760 mmHg
• Flash Point: 261.7 °C
• PSA: 64.21000
• Density: 1.34 g/cm³
• LogP: 2.51130
• Storage Temp.: 2-8°C

Purity/Quality:

98%Min ^*data from raw suppliers

4-Methoxy-1-Methoxycarbonyl-beta-Carboline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Methoxy-1-methoxycarbonyl-beta-carboline

There total 21 articles about 4-Methoxy-1-methoxycarbonyl-beta-carboline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

9-diethoxyphosphoryl-1-cyano-4-methoxy-β-carboline (137936-97-1) → 4-methoxy-β-carboline-1-carboxylic acid methyl ester (60807-25-2)

Guidance literature:

With hydrogenchloride; In methanol; Ambient temperature;

DOI:10.1248/cpb.39.2170

Reference yield: 90.0%

1-cyano-4-methoxy-β-carboline (137936-96-0) → 4-methoxy-β-carboline-1-carboxylic acid methyl ester (60807-25-2)

Guidance literature:

With hydrogenchloride; In methanol; Ambient temperature;

DOI:10.1248/cpb.39.2170

Reference yield: 90.0%

methanol (67-56-1) + 1-cyano-4-methoxy-β-carboline (137936-96-0) → 4-methoxy-β-carboline-1-carboxylic acid methyl ester (60807-25-2)

Guidance literature:

With hydrogenchloride; In dichloromethane; 1.) room temperature, 24 h, 2.) reflux, 10 h;

DOI:10.1016/S0040-4020(96)01112-X

upstream raw materials:

1-cyano-4-methoxy-β-carboline

9-diethoxyphosphoryl-1-cyano-4-methoxy-β-carboline

methanol

1H-indol-2-ylcarboxaldehyde

Downstream raw materials:

picrasidine H

1-methoxycanthin-6-one

4-methoxy-β-carboline-1-carbaldehyde

Refernces

• 1、 Suzuki,Yokoyama,Miyagi,Murakami. "A new general synthetic route for 1-substituted 4-oxygenated β-carbolines". . p. 2170 - 2172. Retrieved 2007/10/02.