decanoic acid (1-(R)-{[4-hydroxy-3-(hydroxymethyl)phenyl]carbamoyl}-ethyl)-amide

Base Information

• Chemical Name: decanoic acid (1-(R)-{[4-hydroxy-3-(hydroxymethyl)phenyl]carbamoyl}-ethyl)-amide
• CAS No.: 400723-16-2
• Molecular Formula: C₂₀H₃₂N₂O₄
• Molecular Weight: 364.485
• Mol file: 400723-16-2.mol

Synonyms:decanoic acid (1-(R)-{[4-hydroxy-3-(hydroxymethyl)phenyl]carbamoyl}-ethyl)-amide

Chemical Property of decanoic acid (1-(R)-{[4-hydroxy-3-(hydroxymethyl)phenyl]carbamoyl}-ethyl)-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of decanoic acid (1-(R)-{[4-hydroxy-3-(hydroxymethyl)phenyl]carbamoyl}-ethyl)-amide

There total 3 articles about decanoic acid (1-(R)-{[4-hydroxy-3-(hydroxymethyl)phenyl]carbamoyl}-ethyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

4-amino-2-hydroxymethylphenol (104333-09-7) + N-decanoyl-D-alanine (22220-05-9) → decanoic acid (1-(R)-{[4-hydroxy-3-(hydroxymethyl)phenyl]carbamoyl}-ethyl)-amide (400723-16-2)

Guidance literature:

With 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 0 - 20 ℃;

DOI:10.1016/S0968-0896(01)00165-1

Reference yield:

methyl 5-amino-2-hydroxybenzoate (42753-75-3) → decanoic acid (1-(R)-{[4-hydroxy-3-(hydroxymethyl)phenyl]carbamoyl}-ethyl)-amide (400723-16-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / lithium aluminium hydride / tetrahydrofuran

2: 26 percent / 1-hydroxybenzotriazole hydrate; 1,3-dicyclohexylcarbodiimide / dimethylformamide / 0 - 20 °C

With lithium aluminium tetrahydride; 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/S0968-0896(01)00165-1

Reference yield:

n-decanoyl chloride (112-13-0) → decanoic acid (1-(R)-{[4-hydroxy-3-(hydroxymethyl)phenyl]carbamoyl}-ethyl)-amide (400723-16-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 58 percent / sodium bicarbonate / H₂O; tetrahydrofuran / 18 h / 20 °C

2: 26 percent / 1-hydroxybenzotriazole hydrate; 1,3-dicyclohexylcarbodiimide / dimethylformamide / 0 - 20 °C

With sodium hydrogencarbonate; 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; In tetrahydrofuran; water; N,N-dimethyl-formamide; 1: Schotten-Baumann reaction;

DOI:10.1016/S0968-0896(01)00165-1

upstream raw materials:

4-amino-2-hydroxymethylphenol

N-decanoyl-D-alanine

methyl 5-amino-2-hydroxybenzoate

n-decanoyl chloride