4-Amino-2-(hydroxymethyl)phenol

Base Information

• Chemical Name: 4-Amino-2-(hydroxymethyl)phenol
• CAS No.: 104333-09-7
• Molecular Formula: C7H9 N O2
• Molecular Weight: 139.154
• DSSTox Substance ID: DTXSID30377156
• Nikkaji Number: J35.808H
• Wikidata: Q33153938
• Mol file: 104333-09-7.mol

Synonyms:4-amino-2-(hydroxymethyl)phenol;104333-09-7;4-amino-2-(hydroxymethyl)benzenol;edinol;5-Aminosaligenin;Oprea1_438487;SCHEMBL33926;DTXSID30377156;MFCD03425760;AKOS005070212;SB84154;CS-0321418;FT-0680312;EN300-7270597;3T-0288;J-514304;Q33153938

Chemical Property of 4-Amino-2-(hydroxymethyl)phenol

Chemical Property:

• Vapor Pressure: 0.000305mmHg at 25°C
• Melting Point: 147-149°C
• Boiling Point: 311.6°Cat760mmHg
• Flash Point: 142.2°C
• PSA: 66.48000
• Density: 1.338g/cm³
• LogP: 1.04790
• Storage Temp.: 2-8°C
• XLogP3: 0.3
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 139.063328530
• Heavy Atom Count: 10
• Complexity: 108

Purity/Quality:

97% ^*data from raw suppliers

4-Amino-2-(hydroxymethyl)benzenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C=C1N)CO)O

Technology Process of 4-Amino-2-(hydroxymethyl)phenol

There total 7 articles about 4-Amino-2-(hydroxymethyl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-hydroxy-5-nitrobenzyl alcohol (39224-61-8) → 4-amino-2-hydroxymethylphenol (104333-09-7)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 5h;

DOI:10.1002/1099-0690(200101)2001:1<137::AID-EJOC137>3.0.CO;2-#

Reference yield: 92.0%

methyl 5-amino-2-hydroxybenzoate (42753-75-3) → 4-amino-2-hydroxymethylphenol (104333-09-7)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran;

DOI:10.1016/S0968-0896(01)00165-1

Reference yield:

5-Nitrosalicylaldehyde (97-51-8) → 4-amino-2-hydroxymethylphenol (104333-09-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 99 percent / NaBH₄ / ethanol

2: 97 percent / H₂ / Pd-C / methanol / 5 h

With sodium tetrahydroborate; hydrogen; palladium on activated charcoal; In methanol; ethanol;

DOI:10.1002/1099-0690(200101)2001:1<137::AID-EJOC137>3.0.CO;2-#

upstream raw materials:

2-hydroxy-5-nitrobenzyl alcohol

phenylhydrazine

methyl 5-amino-2-hydroxybenzoate

5-Nitrosalicylaldehyde

Downstream raw materials:

2-[(4-Hydroxy-3-hydroxymethyl-phenylamino)-methylene]-malonic acid diethyl ester

[2-hydroxy-1-(4-hydroxy-3-hydroxymethyl-phenylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester

4-azido-2-(tert-butyl-dimethyl-silanyloxymethyl)-phenol

(2S,3R,4R)-4-(4-Azido-2-hydroxymethyl-phenoxy)-3-methoxycarbonylmethyl-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester