N-(4-chlorophenyl)-4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butanamide

Base Information

• Chemical Name: N-(4-chlorophenyl)-4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butanamide
• CAS No.: 43226-73-9
• Molecular Formula: C₁₈H₁₅ClN₂O₃
• Molecular Weight: 342.782

Synonyms:N-(4-chlorophenyl)-4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butanamide

Chemical Property of N-(4-chlorophenyl)-4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butanamide

Chemical Property:

Purity/Quality:

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Technology Process of N-(4-chlorophenyl)-4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butanamide

There total 3 articles about N-(4-chlorophenyl)-4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

4-phthalimidobutyric acid (3130-75-4) + 4-chloro-aniline (106-47-8) → N-(4-chlorophenyl)-4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butanamide (43226-73-9)

Guidance literature:

With dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 3 ℃;

DOI:10.1016/j.ejmech.2006.08.010

Reference yield:

phthalic anhydride (85-44-9) → N-(4-chlorophenyl)-4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butanamide (43226-73-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 0.5 h / 180 - 185 °C

2: dicyclohexyl-carbodiimide / dichloromethane / 0 - 3 °C

With dicyclohexyl-carbodiimide; In dichloromethane;

DOI:10.1007/s00044-011-9743-9

Reference yield:

→ N-(4-chlorophenyl)-4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butanamide (43226-73-9)

Guidance literature:

4-Phthalimidobutanoylchlorid, p-Chloranilin;

upstream raw materials:

4-phthalimidobutyric acid

4-chloro-aniline

phthalic anhydride

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