4-Phthalimidobutyric acid

Base Information

• Chemical Name: 4-Phthalimidobutyric acid
• CAS No.: 3130-75-4
• Molecular Formula: C12H11NO4
• Molecular Weight: 233.224
• Hs Code.: 2925190090
• European Community (EC) Number: 675-285-3
• NSC Number: 119133
• UNII: PCM63TY4C3
• DSSTox Substance ID: DTXSID10185231
• Nikkaji Number: J68.624G
• Wikidata: Q72472781
• ChEMBL ID: CHEMBL81673
• Mol file: 3130-75-4.mol

Synonyms:4-phthalimidobutyric acid;4-phthalimidobutyric acid, chloride

Chemical Property of 4-Phthalimidobutyric acid

Chemical Property:

• Vapor Pressure: 1.36E-08mmHg at 25°C
• Melting Point: 119-121 °C
• Refractive Index: 1.605
• Boiling Point: 442.1 °C at 760 mmHg
• PKA: 4.63±0.10(Predicted)
• Flash Point: 221.2 °C
• PSA: 74.68000
• Density: 1.389 g /cm³
• LogP: 1.08530
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility.: Chloroform (Slightly), DMSO (Slightly)
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 233.06880783
• Heavy Atom Count: 17
• Complexity: 328

Purity/Quality:

99%, ^*data from raw suppliers

4-Phthalimidobutyric Acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C(=O)N(C2=O)CCCC(=O)O
• Uses: 4-Phthalimidobutyric Acid can be used to evaluate nootropicactivity of newly synthesized gaba derivative in mice.

Technology Process of 4-Phthalimidobutyric acid

There total 27 articles about 4-Phthalimidobutyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

phthalic anhydride (85-44-9) + 4-amino-n-butyric acid (56-12-2) → 4-phthalimidobutyric acid (3130-75-4)

Guidance literature:

at 170 ℃; for 6h;

DOI:10.1002/ejoc.200601067

Reference yield: 96.0%

potassium phtalimide (1074-82-4) + 4-amino-n-butyric acid (56-12-2) → 4-phthalimidobutyric acid (3130-75-4)

Guidance literature:

at 180 ℃; for 0.5h;

Reference yield: 90.0%

benzene-1,2-dicarboxylic acid (88-99-3,73607-73-5) + 4-amino-n-butyric acid (56-12-2) → 4-phthalimidobutyric acid (3130-75-4)

Guidance literature:

With propionic acid; for 4h; Heating;

DOI:10.1023/A:1021218828915

upstream raw materials:

4-butanolide

potassium phtalimide

phthalic anhydride

4-amino-n-butyric acid

Downstream raw materials:

4-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-butyric acid methyl ester

2-[(4Z)-4-hydroxy-6-oxo-6-phenylhex-4-en-1-yl]-1H-isoindole-1,3(2H)-dione

4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-(4-methylphenyl)butanamide

N-(4-chlorophenyl)-4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butanamide

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