(3aR,4S,5S,11bS)-dimethyl 3-benzyl-2,3,3a,4,5,7-hexahydro-4-[(2R)-2-ethyl-2,3-(dihydroxy)propyl]-1H-pyrrolo[2,3-d]carbazole-5,6-dicarboxylate

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Chemical Name:(3aR,4S,5S,11bS)-dimethyl 3-benzyl-2,3,3a,4,5,7-hexahydro-4-[(2R)-2-ethyl-2,3-(dihydroxy)propyl]-1H-pyrrolo[2,3-d]carbazole-5,6-dicarboxylate
CAS No.:362517-04-2
Molecular Formula:C₃₀H₃₆N₂O₆
Molecular Weight:520.626
Hs Code.:

Synonyms:(3aR,4S,5S,11bS)-dimethyl 3-benzyl-2,3,3a,4,5,7-hexahydro-4-[(2R)-2-ethyl-2,3-(dihydroxy)propyl]-1H-pyrrolo[2,3-d]carbazole-5,6-dicarboxylate

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Chemical Property of (3aR,4S,5S,11bS)-dimethyl 3-benzyl-2,3,3a,4,5,7-hexahydro-4-[(2R)-2-ethyl-2,3-(dihydroxy)propyl]-1H-pyrrolo[2,3-d]carbazole-5,6-dicarboxylate

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Technology Process of (3aR,4S,5S,11bS)-dimethyl 3-benzyl-2,3,3a,4,5,7-hexahydro-4-[(2R)-2-ethyl-2,3-(dihydroxy)propyl]-1H-pyrrolo[2,3-d]carbazole-5,6-dicarboxylate

There total 3 articles about (3aR,4S,5S,11bS)-dimethyl 3-benzyl-2,3,3a,4,5,7-hexahydro-4-[(2R)-2-ethyl-2,3-(dihydroxy)propyl]-1H-pyrrolo[2,3-d]carbazole-5,6-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 362516-77-6
(3aR,4S,5S,11bS)-dimethyl 3-benzyl-2,3,3a,4,5,7-hexahydro-4-[(2R)-2-ethyl-2,3-(isopropylidenedioxy)propyl]-1H-pyrrolo[2,3-d]carbazole-5,6-dicarboxylate

: 362517-04-2
(3aR,4S,5S,11bS)-dimethyl 3-benzyl-2,3,3a,4,5,7-hexahydro-4-[(2R)-2-ethyl-2,3-(dihydroxy)propyl]-1H-pyrrolo[2,3-d]carbazole-5,6-dicarboxylate

Guidance literature:: With hydrogenchloride; In methanol; for 0.25h; Heating;
DOI:10.1021/jo000250y

Reference yield: 13.6%

: 67-64-1
acetone

: 362517-06-4
(3aR,4S,5S,11bS)-dimethyl 3-benzyl-2,3,3a,4,5,7-hexahydro-4-[(2R)-2-ethyl-2,3-epoxypropyl]-1H-pyrrolo[2,3-d]carbazole-5,6-dicarboxylate

: 362517-09-7
(3aR,4S,5S,11bS)-dimethyl 3-benzyl-2,3,3a,4,5,7-hexahydro-4-[(2S)-2-ethyl-2,3-(isopropylidenedioxy)propyl]-1H-pyrrolo[2,3-d]carbazole-5,6-dicarboxylate

: 362517-04-2
(3aR,4S,5S,11bS)-dimethyl 3-benzyl-2,3,3a,4,5,7-hexahydro-4-[(2R)-2-ethyl-2,3-(dihydroxy)propyl]-1H-pyrrolo[2,3-d]carbazole-5,6-dicarboxylate

: 362517-07-5
(3aR,4S,5S,11bS)-dimethyl 3-benzyl-2,3,3a,4,5,7-hexahydro-4-[(2S)-2-ethyl-2,3-dihydroxypropyl]-1H-pyrrolo[2,3-d]carbazole-5,6-dicarboxylate

Guidance literature:: With sulfuric acid; water; silica gel; In 1,4-dioxane; for 0.166667h;
DOI:10.1021/jo000250y

Reference yield:

: 362517-05-3
(3aR,4S,5S,11bS)-dimethyl 3-benzyl-2,3,3a,4,5,7-hexahydro-4-[(2R)-2-ethyl-2-hydroxy-3-tosyloxypropyl]-1H-pyrrolo[2,3-d]carbazole-5,6-dicarboxylate

: 362517-04-2
(3aR,4S,5S,11bS)-dimethyl 3-benzyl-2,3,3a,4,5,7-hexahydro-4-[(2R)-2-ethyl-2,3-(dihydroxy)propyl]-1H-pyrrolo[2,3-d]carbazole-5,6-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 96.3 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 8 h

2: sulfuric acid/silica gel; water / dioxane / 0.17 h

With sulfuric acid; water; silica gel; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1021/jo000250y