(R)-4-((R)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-(6-chloro-2,3-difluoro-4-trifluoromethyl-benzyl)-4-oxo-butyraldehyde

Base Information

Chemical Name:(R)-4-((R)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-(6-chloro-2,3-difluoro-4-trifluoromethyl-benzyl)-4-oxo-butyraldehyde
CAS No.:955406-20-9
Molecular Formula:C₂₂H₁₇ClF₅NO₄
Molecular Weight:489.826
Hs Code.:

Synonyms:(R)-4-((R)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-(6-chloro-2,3-difluoro-4-trifluoromethyl-benzyl)-4-oxo-butyraldehyde

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Chemical Property of (R)-4-((R)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-(6-chloro-2,3-difluoro-4-trifluoromethyl-benzyl)-4-oxo-butyraldehyde

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Technology Process of (R)-4-((R)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-(6-chloro-2,3-difluoro-4-trifluoromethyl-benzyl)-4-oxo-butyraldehyde

There total 4 articles about (R)-4-((R)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-(6-chloro-2,3-difluoro-4-trifluoromethyl-benzyl)-4-oxo-butyraldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 955406-19-6
(R)-4-Benzyl-3-[(S)-2-(6-chloro-2,3-difluoro-4-trifluoromethyl-benzyl)-pent-4-enoyl]-oxazolidin-2-one

: 955406-20-9
(R)-4-((R)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-(6-chloro-2,3-difluoro-4-trifluoromethyl-benzyl)-4-oxo-butyraldehyde

Guidance literature:: With sodium periodate; osmium(VIII) oxide; In tetrahydrofuran; water; tert-butyl alcohol; at 20 ℃; for 4h;

Reference yield:

: 914635-79-3
1-chloro-2-chloromethyl-3,4-difluoro-5-trifluoromethyl-benzene

: 955406-20-9
(R)-4-((R)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-(6-chloro-2,3-difluoro-4-trifluoromethyl-benzyl)-4-oxo-butyraldehyde

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium iodide / acetone / 1 h / 20 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C

2.2: 4 h / 20 °C

3.1: sodium periodate / osmium(VIII) oxide / tetrahydrofuran; water; tert-butyl alcohol / 4 h / 20 °C

With sodium periodate; sodium iodide; lithium hexamethyldisilazane; osmium(VIII) oxide; In tetrahydrofuran; water; acetone; tert-butyl alcohol;

Reference yield:

: 40217-17-2,90719-32-7,120574-96-1,102029-44-7
(R)-4-(phenylmethyl)-2-oxazolidinone

: 955406-20-9
(R)-4-((R)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-(6-chloro-2,3-difluoro-4-trifluoromethyl-benzyl)-4-oxo-butyraldehyde

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 - 20 °C / Cooling with acetone-dry ice

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C

2.2: 4 h / 20 °C

3.1: sodium periodate / osmium(VIII) oxide / tetrahydrofuran; water; tert-butyl alcohol / 4 h / 20 °C

With sodium periodate; n-butyllithium; lithium hexamethyldisilazane; osmium(VIII) oxide; In tetrahydrofuran; water; tert-butyl alcohol;