(R)-3-(6-Chloro-2,3-difluoro-4-trifluoromethyl-benzyl)-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one

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Chemical Name:(R)-3-(6-Chloro-2,3-difluoro-4-trifluoromethyl-benzyl)-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one
CAS No.:955407-48-4
Molecular Formula:C₁₉H₁₇ClF₅N₃O
Molecular Weight:433.808
Hs Code.:

Synonyms:(R)-3-(6-Chloro-2,3-difluoro-4-trifluoromethyl-benzyl)-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one

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Chemical Property of (R)-3-(6-Chloro-2,3-difluoro-4-trifluoromethyl-benzyl)-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one

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Technology Process of (R)-3-(6-Chloro-2,3-difluoro-4-trifluoromethyl-benzyl)-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one

There total 8 articles about (R)-3-(6-Chloro-2,3-difluoro-4-trifluoromethyl-benzyl)-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 955406-20-9
(R)-4-((R)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-(6-chloro-2,3-difluoro-4-trifluoromethyl-benzyl)-4-oxo-butyraldehyde

: 4,5,6,7-tetrahydro-2H-indazol-5-ylamine

: 955407-48-4
(R)-3-(6-Chloro-2,3-difluoro-4-trifluoromethyl-benzyl)-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one

Guidance literature:: (R)-4-((R)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-(6-chloro-2,3-difluoro-4-trifluoromethyl-benzyl)-4-oxo-butyraldehyde; 4,5,6,7-tetrahydro-2H-indazol-5-ylamine; With acetic acid; In methanol; dichloromethane; at 20 ℃; for 0.5h;

With sodium tris(acetoxy)borohydride; In methanol; dichloromethane; at 20 ℃;

With ammonia; In methanol;

Reference yield:

: 914635-79-3
1-chloro-2-chloromethyl-3,4-difluoro-5-trifluoromethyl-benzene

: 955407-48-4
(R)-3-(6-Chloro-2,3-difluoro-4-trifluoromethyl-benzyl)-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium iodide / acetone / 1 h / 20 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C

2.2: 4 h / 20 °C

3.1: sodium periodate / osmium(VIII) oxide / tetrahydrofuran; water; tert-butyl alcohol / 4 h / 20 °C

4.1: acetic acid / methanol; dichloromethane / 0.5 h / 20 °C

4.2: 20 °C

With sodium periodate; acetic acid; sodium iodide; lithium hexamethyldisilazane; osmium(VIII) oxide; In tetrahydrofuran; methanol; dichloromethane; water; acetone; tert-butyl alcohol;

Reference yield:

: 955406-18-5
1-Chloro-3,4-difluoro-2-iodomethyl-5-trifluoromethyl-benzene

: 955407-48-4
(R)-3-(6-Chloro-2,3-difluoro-4-trifluoromethyl-benzyl)-1-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C

1.2: 4 h / 20 °C

2.1: sodium periodate / osmium(VIII) oxide / tetrahydrofuran; water; tert-butyl alcohol / 4 h / 20 °C

3.1: acetic acid / methanol; dichloromethane / 0.5 h / 20 °C

3.2: 20 °C

With sodium periodate; acetic acid; lithium hexamethyldisilazane; osmium(VIII) oxide; In tetrahydrofuran; methanol; dichloromethane; water; tert-butyl alcohol;