1-methoxy-4-(3-phenyl-1-(p-tolyl)propyl)benzene

Base Information

• Chemical Name: 1-methoxy-4-(3-phenyl-1-(p-tolyl)propyl)benzene
• CAS No.: 1512864-44-6
• Molecular Formula: C₂₃H₂₄O
• Molecular Weight: 316.443
• Mol file: 1512864-44-6.mol

Synonyms:1-methoxy-4-(3-phenyl-1-(p-tolyl)propyl)benzene

Chemical Property of 1-methoxy-4-(3-phenyl-1-(p-tolyl)propyl)benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-methoxy-4-(3-phenyl-1-(p-tolyl)propyl)benzene

There total 5 articles about 1-methoxy-4-(3-phenyl-1-(p-tolyl)propyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-tolyl iodide (624-31-7) + 2-[1-(4-methoxyphenyl)-3-phenylpropyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1272031-57-8) → 1-methoxy-4-(3-phenyl-1-(p-tolyl)propyl)benzene (1512864-44-6)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; triphenylphosphine; silver(l) oxide; In 1,4-dioxane; at 90 ℃; for 24h; Inert atmosphere; Schlenk technique; Sealed tube;

DOI:10.1021/ol403338s

Reference yield:

3-phenylpropanal p-tosylhydrazone (61124-61-6) → 1-methoxy-4-(3-phenyl-1-(p-tolyl)propyl)benzene (1512864-44-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / toluene; mineral oil / 1 h / 20 °C / Inert atmosphere; Schlenk technique

1.2: 12 h / 110 °C / Inert atmosphere; Schlenk technique; Sealed tube

2.1: potassium hydroxide; bis(tri-tert-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane; water / 6 h / 25 °C / Inert atmosphere; Sealed tube

3.1: triphenylphosphine; silver(l) oxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 24 h / 90 °C / Inert atmosphere; Schlenk technique; Sealed tube

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; bis(tri-tert-butylphosphine)palladium⁽⁰⁾; sodium hydride; triphenylphosphine; potassium hydroxide; silver(l) oxide; In 1,4-dioxane; water; toluene; mineral oil;

DOI:10.1021/ol403338s

Reference yield:

3-phenyl-propionaldehyde (104-53-0) → 1-methoxy-4-(3-phenyl-1-(p-tolyl)propyl)benzene (1512864-44-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: methanol / 20 °C / Inert atmosphere

2.1: sodium hydride / toluene; mineral oil / 1 h / 20 °C / Inert atmosphere; Schlenk technique

2.2: 12 h / 110 °C / Inert atmosphere; Schlenk technique; Sealed tube

3.1: potassium hydroxide; bis(tri-tert-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane; water / 6 h / 25 °C / Inert atmosphere; Sealed tube

4.1: triphenylphosphine; silver(l) oxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 24 h / 90 °C / Inert atmosphere; Schlenk technique; Sealed tube

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; bis(tri-tert-butylphosphine)palladium⁽⁰⁾; sodium hydride; triphenylphosphine; potassium hydroxide; silver(l) oxide; In 1,4-dioxane; methanol; water; toluene; mineral oil;

DOI:10.1021/ol403338s

upstream raw materials:

3-phenyl-propionaldehyde

3-phenylpropanal p-tosylhydrazone

4,4,5,5‐tetramethyl‐2‐[5‐phenyl‐1‐(4,4,5,5‐tetramethyl‐1,3,2‐dioxaborolan‐2‐yl)propyl]‐1,3,2‐dioxaborolane

1-bromo-4-methoxy-benzene