4,4,5,5‐tetramethyl‐2‐[5‐phenyl‐1‐(4,4,5,5‐tetramethyl‐1,3,2‐dioxaborolan‐2‐yl)propyl]‐1,3,2‐dioxaborolane

Base Information

• Chemical Name: 4,4,5,5‐tetramethyl‐2‐[5‐phenyl‐1‐(4,4,5,5‐tetramethyl‐1,3,2‐dioxaborolan‐2‐yl)propyl]‐1,3,2‐dioxaborolane
• CAS No.: 1379610-52-2
• Molecular Formula: C₂₁H₃₄B₂O₄
• Molecular Weight: 372.121
• Mol file: 1379610-52-2.mol

Synonyms:4,4,5,5‐tetramethyl‐2‐[5‐phenyl‐1‐(4,4,5,5‐tetramethyl‐1,3,2‐dioxaborolan‐2‐yl)propyl]‐1,3,2‐dioxaborolane

Chemical Property of 4,4,5,5‐tetramethyl‐2‐[5‐phenyl‐1‐(4,4,5,5‐tetramethyl‐1,3,2‐dioxaborolan‐2‐yl)propyl]‐1,3,2‐dioxaborolane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4,4,5,5‐tetramethyl‐2‐[5‐phenyl‐1‐(4,4,5,5‐tetramethyl‐1,3,2‐dioxaborolan‐2‐yl)propyl]‐1,3,2‐dioxaborolane

There total 16 articles about 4,4,5,5‐tetramethyl‐2‐[5‐phenyl‐1‐(4,4,5,5‐tetramethyl‐1,3,2‐dioxaborolan‐2‐yl)propyl]‐1,3,2‐dioxaborolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

3-phenylpropanal p-tosylhydrazone (61124-61-6) + bis(pinacol)diborane (73183-34-3) → 4,4,5,5‐tetramethyl‐2‐[5‐phenyl‐1‐(4,4,5,5‐tetramethyl‐1,3,2‐dioxaborolan‐2‐yl)propyl]‐1,3,2‐dioxaborolane (1379610-52-2)

Guidance literature:

3-phenylpropanal p-tosylhydrazone; With sodium hydride; In toluene; mineral oil; at 20 ℃; for 1h; Inert atmosphere; Schlenk technique;

bis(pinacol)diborane; In toluene; mineral oil; at 110 ℃; for 12h; Concentration; Inert atmosphere; Schlenk technique; Sealed tube;

DOI:10.1021/ol403338s

Reference yield: 83.0%

(3,3-dibromopropyl)benzene (134414-86-1) + bis(pinacol)diborane (73183-34-3) → 4,4,5,5‐tetramethyl‐2‐[5‐phenyl‐1‐(4,4,5,5‐tetramethyl‐1,3,2‐dioxaborolan‐2‐yl)propyl]‐1,3,2‐dioxaborolane (1379610-52-2)

Guidance literature:

With copper(l) iodide; lithium methanolate; triphenylphosphine; In N,N-dimethyl-formamide; at 20 ℃; for 24h; Inert atmosphere; Sealed tube;

DOI:10.1021/ja500029w

Reference yield: 83.0%

propargyl benzene (10147-11-2) + 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane (25015-63-8) → 4,4,5,5‐tetramethyl‐2‐[5‐phenyl‐1‐(4,4,5,5‐tetramethyl‐1,3,2‐dioxaborolan‐2‐yl)propyl]‐1,3,2‐dioxaborolane (1379610-52-2)

Guidance literature:

4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane; With 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; copper(l) chloride; sodium t-butanolate; In toluene; at 20 ℃; for 0.166667h; Schlenk technique; Inert atmosphere;

propargyl benzene; In toluene; at 20 ℃; for 24h; regioselective reaction; Schlenk technique; Inert atmosphere;

DOI:10.1002/asia.201402458

upstream raw materials:

bis(pinacol)diborane

3-phenyl-propionaldehyde

3-phenylpropanal p-tosylhydrazone

(3,3-dibromopropyl)benzene

Downstream raw materials:

4,4,5,5-tetramethyl-2-(3-phenylpropyl)-[1,3,2]dioxaborolane

methyl 4-(1,3-diphenylpropyl)benzoate

(1-(4-methoxyphenyl)propane-1,3-diyl)dibenzene

methyl 4-(1-(4-fluorophenyl)-3-phenylpropyl)benzoate