((1R,2R,4R)-4-Benzenesulfonylmethyl-2-methoxy-cyclohexyloxy)-tert-butyl-diphenyl-silane

Base Information

Chemical Name:((1R,2R,4R)-4-Benzenesulfonylmethyl-2-methoxy-cyclohexyloxy)-tert-butyl-diphenyl-silane
CAS No.:128694-54-2
Molecular Formula:C₃₀H₃₈O₄SSi
Molecular Weight:522.781
Hs Code.:

Synonyms:((1R,2R,4R)-4-Benzenesulfonylmethyl-2-methoxy-cyclohexyloxy)-tert-butyl-diphenyl-silane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ((1R,2R,4R)-4-Benzenesulfonylmethyl-2-methoxy-cyclohexyloxy)-tert-butyl-diphenyl-silane

Chemical Property:

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Technology Process of ((1R,2R,4R)-4-Benzenesulfonylmethyl-2-methoxy-cyclohexyloxy)-tert-butyl-diphenyl-silane

There total 7 articles about ((1R,2R,4R)-4-Benzenesulfonylmethyl-2-methoxy-cyclohexyloxy)-tert-butyl-diphenyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 127258-20-2
(1R,2R,4R)-2-methoxy-4-<(phenylsulfonyl)methyl>-1-cyclohexanol

: 58479-61-1
tert-butylchlorodiphenylsilane

: 128694-54-2
((1R,2R,4R)-4-Benzenesulfonylmethyl-2-methoxy-cyclohexyloxy)-tert-butyl-diphenyl-silane

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; Ambient temperature;
DOI:10.1016/S0040-4039(01)93398-2

Reference yield:

: 5709-98-8
(R)-cyclohex-3-enecarboxylic acid

: 128694-54-2
((1R,2R,4R)-4-Benzenesulfonylmethyl-2-methoxy-cyclohexyloxy)-tert-butyl-diphenyl-silane

Guidance literature:: Multi-step reaction with 8 steps

1: 93 percent / I₂/KI, NaHCO₃ / H₂O / 0 °C

2: 96 percent / DBU / tetrahydrofuran / Heating

3: 93 percent / LiAlH₄ / diethyl ether / 0 °C

4: 70 percent / n-Bu₃P / dimethylformamide / Ambient temperature

5: 94 percent / BF₃*Et₂O / diethyl ether / 0 °C

6: 87 percent / oxone / tetrahydrofuran; methanol; H₂O / 0 °C

7: 71 percent / BH₃*THF, NaOH, t-BuO₂H / -78 deg C to room temp.

8: 70 percent / imidazole / dimethylformamide / Ambient temperature

With 1H-imidazole; tert.-butylhydroperoxide; Oxone; sodium hydroxide; lithium aluminium tetrahydride; borane-THF; tributylphosphine; boron trifluoride diethyl etherate; iodine; sodium hydrogencarbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; potassium iodide; In tetrahydrofuran; methanol; diethyl ether; water; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(01)93398-2

Reference yield:

: 127308-75-2
(1R,5R)-5-(hydroxymethyl)-2-cyclohexen-1-ol

: 128694-54-2
((1R,2R,4R)-4-Benzenesulfonylmethyl-2-methoxy-cyclohexyloxy)-tert-butyl-diphenyl-silane

Guidance literature:: Multi-step reaction with 5 steps

1: 70 percent / n-Bu₃P / dimethylformamide / Ambient temperature

2: 94 percent / BF₃*Et₂O / diethyl ether / 0 °C

3: 87 percent / oxone / tetrahydrofuran; methanol; H₂O / 0 °C

4: 71 percent / BH₃*THF, NaOH, t-BuO₂H / -78 deg C to room temp.

5: 70 percent / imidazole / dimethylformamide / Ambient temperature

With 1H-imidazole; tert.-butylhydroperoxide; Oxone; sodium hydroxide; borane-THF; tributylphosphine; boron trifluoride diethyl etherate; In tetrahydrofuran; methanol; diethyl ether; water; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(01)93398-2