Methyl (2S,4'S,5'S)-2-(2'-benzyloxy-5'-phenyl-1',3'-oxazolin-4'-yl)-2-hydroxyacetate

Base Information

Chemical Name:Methyl (2S,4'S,5'S)-2-(2'-benzyloxy-5'-phenyl-1',3'-oxazolin-4'-yl)-2-hydroxyacetate
CAS No.:226701-30-0
Molecular Formula:C₁₉H₁₉NO₅
Molecular Weight:341.364
Hs Code.:

Synonyms:Methyl (2S,4'S,5'S)-2-(2'-benzyloxy-5'-phenyl-1',3'-oxazolin-4'-yl)-2-hydroxyacetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Methyl (2S,4'S,5'S)-2-(2'-benzyloxy-5'-phenyl-1',3'-oxazolin-4'-yl)-2-hydroxyacetate

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Technology Process of Methyl (2S,4'S,5'S)-2-(2'-benzyloxy-5'-phenyl-1',3'-oxazolin-4'-yl)-2-hydroxyacetate

There total 3 articles about Methyl (2S,4'S,5'S)-2-(2'-benzyloxy-5'-phenyl-1',3'-oxazolin-4'-yl)-2-hydroxyacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 226701-29-7
Methyl (4'R,5'S)-2-(2'-benzyloxy-5'-phenyl-1',3'-oxazolin-4'-yl)acetate

: 226701-30-0
Methyl (2S,4'S,5'S)-2-(2'-benzyloxy-5'-phenyl-1',3'-oxazolin-4'-yl)-2-hydroxyacetate

Guidance literature:: With N-(benzenesulfonyl)-3-phenyloxaziridine; lithium hexamethyldisilazane; In tetrahydrofuran; 1.) -78 deg C, 1 h, 2.) -78 deg C, 1 h;
DOI:10.1055/s-1999-3495

Reference yield:

: 100-39-0
benzyl bromide

: 226701-30-0
Methyl (2S,4'S,5'S)-2-(2'-benzyloxy-5'-phenyl-1',3'-oxazolin-4'-yl)-2-hydroxyacetate

Guidance literature:: Multi-step reaction with 2 steps

1: 83 percent / Ag₂CO₃ / toluene / 6 h / 60 °C

2: 62 percent / LiHMDS, 3-phenyl-2-(phenylsulfonyl)oxaziridine / tetrahydrofuran / 1.) -78 deg C, 1 h, 2.) -78 deg C, 1 h

With N-(benzenesulfonyl)-3-phenyloxaziridine; silver carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; toluene;
DOI:10.1055/s-1999-3495

Reference yield:

: ((4R,5S)-2-Oxo-5-phenyl-oxazolidin-4-yl)-acetic acid methyl ester

: 226701-30-0
Methyl (2S,4'S,5'S)-2-(2'-benzyloxy-5'-phenyl-1',3'-oxazolin-4'-yl)-2-hydroxyacetate

Guidance literature:: Multi-step reaction with 2 steps

1: 83 percent / Ag₂CO₃ / toluene / 6 h / 60 °C

2: 62 percent / LiHMDS, 3-phenyl-2-(phenylsulfonyl)oxaziridine / tetrahydrofuran / 1.) -78 deg C, 1 h, 2.) -78 deg C, 1 h

With N-(benzenesulfonyl)-3-phenyloxaziridine; silver carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; toluene;
DOI:10.1055/s-1999-3495