(R)-3-{(2S,3R)-2-[(1R,2R)-4-Benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-butyl]-5-methoxy-tetrahydro-furan-3-yl}-2-methyl-propionaldehyde

Base Information

Chemical Name:(R)-3-{(2S,3R)-2-[(1R,2R)-4-Benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-butyl]-5-methoxy-tetrahydro-furan-3-yl}-2-methyl-propionaldehyde
CAS No.:80879-47-6
Molecular Formula:C₂₇H₄₆O₅Si
Molecular Weight:478.745
Hs Code.:

Synonyms:(R)-3-{(2S,3R)-2-[(1R,2R)-4-Benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-butyl]-5-methoxy-tetrahydro-furan-3-yl}-2-methyl-propionaldehyde

Suppliers and Price of (R)-3-{(2S,3R)-2-[(1R,2R)-4-Benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-butyl]-5-methoxy-tetrahydro-furan-3-yl}-2-methyl-propionaldehyde

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-3-{(2S,3R)-2-[(1R,2R)-4-Benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-butyl]-5-methoxy-tetrahydro-furan-3-yl}-2-methyl-propionaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-3-{(2S,3R)-2-[(1R,2R)-4-Benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-butyl]-5-methoxy-tetrahydro-furan-3-yl}-2-methyl-propionaldehyde

There total 6 articles about (R)-3-{(2S,3R)-2-[(1R,2R)-4-Benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-butyl]-5-methoxy-tetrahydro-furan-3-yl}-2-methyl-propionaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 135799-73-4,138283-99-5,138284-05-6,138284-13-6,138284-14-7
(2S,3R)-2-<(1R,2R)-4-(Benzyloxy)-2-<(tert-butyldimethylsilyl)oxy>-1-methylbutyl>-3-<(2R)-3-hydroxy-2-methylpropyl>-5-methoxy-1,2,3,4-tetrahydrofuran

: 80879-47-6
(R)-3-{(2S,3R)-2-[(1R,2R)-4-Benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-butyl]-5-methoxy-tetrahydro-furan-3-yl}-2-methyl-propionaldehyde

Guidance literature:: With CrO₃*pyridinium hydrochloride; sodium acetate; In dichloromethane; at 0 ℃; for 2h; Yield given;
DOI:10.1021/ja00371a043

Reference yield:

: 80879-45-4
(4R,5S)-5-((1S,2R)-4-Benzyloxy-2-hydroxy-1-methyl-butyl)-4-(2-methyl-allyl)-dihydro-furan-2-one

: 80879-47-6
(R)-3-{(2S,3R)-2-[(1R,2R)-4-Benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-butyl]-5-methoxy-tetrahydro-furan-3-yl}-2-methyl-propionaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1: Dibal / CH₂Cl₂ / 0.5 h / -78 °C

2: HCl / 0.25 h / 25 °C

3: imidazole / dimethylformamide / 25 °C

4: 1.) BH₃, 2.) NaOH, H₂O₂ / 1.) THF, 0 deg C

5: CrO₃*pyr*HCl, NaOAc / CH₂Cl₂ / 2 h / 0 °C

With 1H-imidazole; hydrogenchloride; sodium hydroxide; CrO₃*pyridinium hydrochloride; borane; dihydrogen peroxide; sodium acetate; diisobutylaluminium hydride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja00371a043

Reference yield:

: (4R,5S)-5-((1S,2R)-4-Benzyloxy-2-hydroxy-1-methyl-butyl)-4-(2-methyl-allyl)-tetrahydro-furan-2-ol

: 80879-47-6
(R)-3-{(2S,3R)-2-[(1R,2R)-4-Benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-butyl]-5-methoxy-tetrahydro-furan-3-yl}-2-methyl-propionaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: HCl / 0.25 h / 25 °C

2: imidazole / dimethylformamide / 25 °C

3: 1.) BH₃, 2.) NaOH, H₂O₂ / 1.) THF, 0 deg C

4: CrO₃*pyr*HCl, NaOAc / CH₂Cl₂ / 2 h / 0 °C

With 1H-imidazole; hydrogenchloride; sodium hydroxide; CrO₃*pyridinium hydrochloride; borane; dihydrogen peroxide; sodium acetate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja00371a043