(4R,5S)-5-((1S,2R)-4-Benzyloxy-2-hydroxy-1-methyl-butyl)-4-(2-methyl-allyl)-dihydro-furan-2-one

Base Information

Chemical Name:(4R,5S)-5-((1S,2R)-4-Benzyloxy-2-hydroxy-1-methyl-butyl)-4-(2-methyl-allyl)-dihydro-furan-2-one
CAS No.:80879-45-4
Molecular Formula:C₂₀H₂₈O₄
Molecular Weight:332.44
Hs Code.:

Synonyms:(4R,5S)-5-((1S,2R)-4-Benzyloxy-2-hydroxy-1-methyl-butyl)-4-(2-methyl-allyl)-dihydro-furan-2-one

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Chemical Property of (4R,5S)-5-((1S,2R)-4-Benzyloxy-2-hydroxy-1-methyl-butyl)-4-(2-methyl-allyl)-dihydro-furan-2-one

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Technology Process of (4R,5S)-5-((1S,2R)-4-Benzyloxy-2-hydroxy-1-methyl-butyl)-4-(2-methyl-allyl)-dihydro-furan-2-one

There total 1 articles about (4R,5S)-5-((1S,2R)-4-Benzyloxy-2-hydroxy-1-methyl-butyl)-4-(2-methyl-allyl)-dihydro-furan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 80879-44-3
3-[(4S,5S,6R)-6-(2-Benzyloxy-ethyl)-2,2,5-trimethyl-[1,3]dioxan-4-yl]-5-methyl-hex-5-enoic acid ethyl ester

: 80879-45-4
(4R,5S)-5-((1S,2R)-4-Benzyloxy-2-hydroxy-1-methyl-butyl)-4-(2-methyl-allyl)-dihydro-furan-2-one

Guidance literature:: With hydrogenchloride; In ethylene glycol; at 25 ℃;
DOI:10.1021/ja00371a043

Reference yield:

: 80879-45-4
(4R,5S)-5-((1S,2R)-4-Benzyloxy-2-hydroxy-1-methyl-butyl)-4-(2-methyl-allyl)-dihydro-furan-2-one

: (4R,5S)-5-((1S,2R)-4-Benzyloxy-2-hydroxy-1-methyl-butyl)-4-(2-methyl-allyl)-tetrahydro-furan-2-ol

Guidance literature:: With diisobutylaluminium hydride; In dichloromethane; at -78 ℃; for 0.5h;
DOI:10.1021/ja00371a043

Reference yield:

: 80879-45-4
(4R,5S)-5-((1S,2R)-4-Benzyloxy-2-hydroxy-1-methyl-butyl)-4-(2-methyl-allyl)-dihydro-furan-2-one

: 135799-73-4,138283-99-5,138284-05-6,138284-13-6,138284-14-7
(2S,3R)-2-<(1R,2R)-4-(Benzyloxy)-2-<(tert-butyldimethylsilyl)oxy>-1-methylbutyl>-3-<(2R)-3-hydroxy-2-methylpropyl>-5-methoxy-1,2,3,4-tetrahydrofuran

Guidance literature:: Multi-step reaction with 4 steps

1: Dibal / CH₂Cl₂ / 0.5 h / -78 °C

2: HCl / 0.25 h / 25 °C

3: imidazole / dimethylformamide / 25 °C

4: 1.) BH₃, 2.) NaOH, H₂O₂ / 1.) THF, 0 deg C

With 1H-imidazole; hydrogenchloride; sodium hydroxide; borane; dihydrogen peroxide; diisobutylaluminium hydride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja00371a043