6-ethyl-3-({4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}amino)-5-(tetrahydro-2H-pyran-4-ylamino)pyrazine-2-carboxamide

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Chemical Name:6-ethyl-3-({4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}amino)-5-(tetrahydro-2H-pyran-4-ylamino)pyrazine-2-carboxamide
CAS No.:1254053-42-3
Molecular Formula:C₂₈H₄₂N₈O₂
Molecular Weight:522.694
Hs Code.:

Synonyms:6-ethyl-3-({4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}amino)-5-(tetrahydro-2H-pyran-4-ylamino)pyrazine-2-carboxamide

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Chemical Property of 6-ethyl-3-({4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}amino)-5-(tetrahydro-2H-pyran-4-ylamino)pyrazine-2-carboxamide

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Technology Process of 6-ethyl-3-({4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}amino)-5-(tetrahydro-2H-pyran-4-ylamino)pyrazine-2-carboxamide

There total 4 articles about 6-ethyl-3-({4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}amino)-5-(tetrahydro-2H-pyran-4-ylamino)pyrazine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: C₂₈H₄₀N₈O

: 1254053-42-3
6-ethyl-3-({4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}amino)-5-(tetrahydro-2H-pyran-4-ylamino)pyrazine-2-carboxamide

Guidance literature:: With dihydrogen peroxide; potassium hydroxide; In methanol; dimethyl sulfoxide; at 20 ℃; for 3h;

Reference yield:

: 2043020-03-5
3-bromo-5-chloro-6-ethylpyrazine-2-carbonitrile

: 1254053-42-3
6-ethyl-3-({4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}amino)-5-(tetrahydro-2H-pyran-4-ylamino)pyrazine-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

2: palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 80 °C / Inert atmosphere

3: dihydrogen peroxide; potassium hydroxide / dimethyl sulfoxide; methanol / 3 h / 20 °C

With dihydrogen peroxide; palladium diacetate; caesium carbonate; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; potassium hydroxide; In 1,4-dioxane; methanol; dichloromethane; dimethyl sulfoxide;

Reference yield:

: C₁₂H₁₅BrN₄O

: 1254053-42-3
6-ethyl-3-({4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}amino)-5-(tetrahydro-2H-pyran-4-ylamino)pyrazine-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 80 °C / Inert atmosphere

2: dihydrogen peroxide; potassium hydroxide / dimethyl sulfoxide; methanol / 3 h / 20 °C

With dihydrogen peroxide; palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; potassium hydroxide; In 1,4-dioxane; methanol; dimethyl sulfoxide;