(R)-tert-butyl 2-(3-cyano-5-fluorophenyl)-4,4-difluoropyrrolidine-1-carboxylate

Base Information

Chemical Name:(R)-tert-butyl 2-(3-cyano-5-fluorophenyl)-4,4-difluoropyrrolidine-1-carboxylate
CAS No.:1364890-36-7
Molecular Formula:C₁₆H₁₇F₃N₂O₂
Molecular Weight:326.318
Hs Code.:

Synonyms:(R)-tert-butyl 2-(3-cyano-5-fluorophenyl)-4,4-difluoropyrrolidine-1-carboxylate

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Chemical Property of (R)-tert-butyl 2-(3-cyano-5-fluorophenyl)-4,4-difluoropyrrolidine-1-carboxylate

Chemical Property:

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Technology Process of (R)-tert-butyl 2-(3-cyano-5-fluorophenyl)-4,4-difluoropyrrolidine-1-carboxylate

There total 6 articles about (R)-tert-butyl 2-(3-cyano-5-fluorophenyl)-4,4-difluoropyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1364890-35-6
(R)-tert-butyl 2-(3-cyano-5-fluorophenyl)-4-oxopyrrolidine-1-carboxylate

: 1364890-36-7
(R)-tert-butyl 2-(3-cyano-5-fluorophenyl)-4,4-difluoropyrrolidine-1-carboxylate

Guidance literature:: With diethylamino-sulfur trifluoride; In dichloromethane; at -78 - 20 ℃; for 12.5h; Plastic bottle;

Reference yield:

: 228267-20-7
tert-butyl (R)-4-((tert-butyldimethylsilyl)oxy)-2-oxopyrrolidine-1-carboxylate

: 1364890-36-7
(R)-tert-butyl 2-(3-cyano-5-fluorophenyl)-4,4-difluoropyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: isopropylmagnesium chloride / diethyl ether; tetrahydrofuran / 1 h / -78 - -30 °C

1.2: 0.5 h / -78 - 0 °C

1.3: 12 h / 20 °C

2.1: triethylamine / dichloromethane / 2 h / -60 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 12 h / 0 - 20 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

5.1: trichloroisocyanuric acid / 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane / 1.25 h / -10 - 20 °C

6.1: diethylamino-sulfur trifluoride / dichloromethane / 12.5 h / -78 - 20 °C / Plastic bottle

With diethylamino-sulfur trifluoride; trichloroisocyanuric acid; tetrabutyl ammonium fluoride; isopropylmagnesium chloride; sodium hydride; triethylamine; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1364890-28-7
tert-butyl ((2R)-2-((tert-butyldimethylsilyl)oxy)-4-(3-cyano-5-fluorophenyl)-4-hydroxybutyl)carbamate

: 1364890-36-7
(R)-tert-butyl 2-(3-cyano-5-fluorophenyl)-4,4-difluoropyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / dichloromethane / 2 h / -60 °C

2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 12 h / 0 - 20 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

4: trichloroisocyanuric acid / 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane / 1.25 h / -10 - 20 °C

5: diethylamino-sulfur trifluoride / dichloromethane / 12.5 h / -78 - 20 °C / Plastic bottle

With diethylamino-sulfur trifluoride; trichloroisocyanuric acid; tetrabutyl ammonium fluoride; sodium hydride; triethylamine; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil;