(4R)-tert-butyl 4-((tert-butyldimethylsilyl)oxy)-2-(3-cyano-5-fluorophenyl)pyrrolidine-1-carboxylate

Base Information

Chemical Name:(4R)-tert-butyl 4-((tert-butyldimethylsilyl)oxy)-2-(3-cyano-5-fluorophenyl)pyrrolidine-1-carboxylate
CAS No.:1364890-30-1
Molecular Formula:C₂₂H₃₃FN₂O₃Si
Molecular Weight:420.6
Hs Code.:

Synonyms:(4R)-tert-butyl 4-((tert-butyldimethylsilyl)oxy)-2-(3-cyano-5-fluorophenyl)pyrrolidine-1-carboxylate

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Chemical Property of (4R)-tert-butyl 4-((tert-butyldimethylsilyl)oxy)-2-(3-cyano-5-fluorophenyl)pyrrolidine-1-carboxylate

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Technology Process of (4R)-tert-butyl 4-((tert-butyldimethylsilyl)oxy)-2-(3-cyano-5-fluorophenyl)pyrrolidine-1-carboxylate

There total 4 articles about (4R)-tert-butyl 4-((tert-butyldimethylsilyl)oxy)-2-(3-cyano-5-fluorophenyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (3R)-4-((tert-butoxycarbonyl)amino)-3-((tert-butyldimethylsilyl)oxy)-1-(3-cyano-5-fluorophenyl)butyl methanesulfonate

: 1364890-30-1
(4R)-tert-butyl 4-((tert-butyldimethylsilyl)oxy)-2-(3-cyano-5-fluorophenyl)pyrrolidine-1-carboxylate

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 12h;

Reference yield:

: 131653-51-5
(4R)-4-((tert-butyl(dimethyl)silyl)oxy)pyrrolidin-2-one

: 1364890-30-1
(4R)-tert-butyl 4-((tert-butyldimethylsilyl)oxy)-2-(3-cyano-5-fluorophenyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: dmap; triethylamine / acetonitrile / 0 - 20 °C / Inert atmosphere

2.1: isopropylmagnesium chloride / tetrahydrofuran / -78 - -30 °C

2.2: 0.5 h / -78 °C

2.3: 0 - 20 °C

3.1: triethylamine; methanesulfonyl chloride / dichloromethane / 2 h / -60 °C

With dmap; isopropylmagnesium chloride; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; dichloromethane; acetonitrile;

Reference yield:

: 228267-20-7
tert-butyl (R)-4-((tert-butyldimethylsilyl)oxy)-2-oxopyrrolidine-1-carboxylate

: 1364890-30-1
(4R)-tert-butyl 4-((tert-butyldimethylsilyl)oxy)-2-(3-cyano-5-fluorophenyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: isopropylmagnesium chloride / tetrahydrofuran / -78 - -30 °C

1.2: 0.5 h / -78 °C

1.3: 0 - 20 °C

2.1: triethylamine; methanesulfonyl chloride / dichloromethane / 2 h / -60 °C

With isopropylmagnesium chloride; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; dichloromethane;