N-benzyl-2-(2-methyl-4-(methylsulfonyl)-1H-indol-1-yl)-5,6,7,8-tetrahydroquinazolin-4-amine

Base Information

Chemical Name:N-benzyl-2-(2-methyl-4-(methylsulfonyl)-1H-indol-1-yl)-5,6,7,8-tetrahydroquinazolin-4-amine
CAS No.:1542706-42-2
Molecular Formula:C₂₅H₂₆N₄O₂S
Molecular Weight:446.573
Hs Code.:

Synonyms:N-benzyl-2-(2-methyl-4-(methylsulfonyl)-1H-indol-1-yl)-5,6,7,8-tetrahydroquinazolin-4-amine

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Chemical Property of N-benzyl-2-(2-methyl-4-(methylsulfonyl)-1H-indol-1-yl)-5,6,7,8-tetrahydroquinazolin-4-amine

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Technology Process of N-benzyl-2-(2-methyl-4-(methylsulfonyl)-1H-indol-1-yl)-5,6,7,8-tetrahydroquinazolin-4-amine

There total 6 articles about N-benzyl-2-(2-methyl-4-(methylsulfonyl)-1H-indol-1-yl)-5,6,7,8-tetrahydroquinazolin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1454256-90-6
N-benzyl-2-chloro-5,6,7,8-tetrahydroquinazolin-4-amine

: 1542711-85-2
2-methyl-4-(methylsulfonyl)-1H-indole

: 1542706-42-2
N-benzyl-2-(2-methyl-4-(methylsulfonyl)-1H-indol-1-yl)-5,6,7,8-tetrahydroquinazolin-4-amine

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; XPhos; In 1,4-dioxane; at 0 - 100 ℃; for 2h; Inert atmosphere;

Reference yield:

: 1542711-81-8
4-iodo-2-methyl-1-(phenylsulfonyl)-1H-indole

: 1542706-42-2
N-benzyl-2-(2-methyl-4-(methylsulfonyl)-1H-indol-1-yl)-5,6,7,8-tetrahydroquinazolin-4-amine

Guidance literature:: Multi-step reaction with 3 steps

1: copper(l) iodide; L-proline / dimethyl sulfoxide / 48 h / 80 °C / Inert atmosphere

2: sodium hydroxide; water / methanol / 0.5 h / 60 °C

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; caesium carbonate / 1,4-dioxane / 2 h / 0 - 100 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; water; caesium carbonate; L-proline; sodium hydroxide; XPhos; In 1,4-dioxane; methanol; dimethyl sulfoxide;

Reference yield:

: 1542711-71-6
2-methyl-4-nitro-1-(phenylsulfonyl)-1H-indole

: 1542706-42-2
N-benzyl-2-(2-methyl-4-(methylsulfonyl)-1H-indol-1-yl)-5,6,7,8-tetrahydroquinazolin-4-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: ammonium chloride; iron / ethanol / 2 h / 60 °C

2.1: sodium nitrite; hydrogenchloride / water / 0.5 h / 0 °C

2.2: 1.67 h / 0 - 85 °C

3.1: copper(l) iodide; L-proline / dimethyl sulfoxide / 48 h / 80 °C / Inert atmosphere

4.1: sodium hydroxide; water / methanol / 0.5 h / 60 °C

5.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; caesium carbonate / 1,4-dioxane / 2 h / 0 - 100 °C / Inert atmosphere

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; water; iron; ammonium chloride; caesium carbonate; L-proline; sodium hydroxide; sodium nitrite; XPhos; In 1,4-dioxane; methanol; ethanol; water; dimethyl sulfoxide;