2-Methyl-4-nitroindole

Base Information

Chemical Name:2-Methyl-4-nitroindole
CAS No.:3484-10-4
Molecular Formula:C9H8 N2 O2
Molecular Weight:176.175
Hs Code.:2933990090
DSSTox Substance ID:DTXSID70454970
Nikkaji Number:J1.134.333C
Wikidata:Q72493592
Mol file:3484-10-4.mol

Synonyms:2-Methyl-4-nitroindole;2-methyl-4-nitro-1H-indole;3484-10-4;MFCD09028445;1H-Indole, 2-methyl-4-nitro-;SCHEMBL1002018;DTXSID70454970;STL573305;AKOS006343026;CS-W003572;DS-1626;PB17582;PS-4379;SY006785;BB 0259759;FT-0646819;FT-0656089

Suppliers and Price of 2-Methyl-4-nitroindole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-Methyl-4-nitroindole
500mg
$ 250.00

TRC
2-Methyl-4-nitroindole
50mg
$ 70.00

SynQuest Laboratories
2-Methyl-4-nitro-1H-indole
100 mg
$ 24.00

SynQuest Laboratories
2-Methyl-4-nitro-1H-indole
500 mg
$ 72.00

Matrix Scientific
2-Methyl-4-nitroindole
500mg
$ 300.00

J&W Pharmlab
2-Methyl-4-nitro-1H-indole 96%
25g
$ 1390.00

J&W Pharmlab
2-Methyl-4-nitro-1H-indole 96%
1g
$ 98.00

J&W Pharmlab
2-Methyl-4-nitro-1H-indole 96%
5g
$ 398.00

Crysdot
2-Methyl-4-nitroindole 97%
5g
$ 281.00

Crysdot
2-Methyl-4-nitroindole 97%
10g
$ 423.00

Total 22 raw suppliers

Chemical Property of 2-Methyl-4-nitroindole

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Melting Point:192-194 °C
Boiling Point:365.6°Cat760mmHg
PKA:15.34±0.30(Predicted)
Flash Point:174.9°C
PSA：61.61000
Density:1.355g/cm³
LogP:2.90770
Storage Temp.:Sealed in dry,Room Temperature
XLogP3:2.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:176.058577502
Heavy Atom Count:13
Complexity:214

Purity/Quality:

97% ^*data from raw suppliers

2-Methyl-4-nitroindole ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xi

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC2=C(N1)C=CC=C2[N+](=O)[O-]
Uses 2-Methyl-4-nitroindole is a useful synthetic intermediate in the synthesis of AZD1981, a CRTH2 receptor antagonist used in patients with moderate to severe COPD. 2-Methyl-4-nitroindole is also used as a reagent in the preparation of anti-angiogenic pyrroloazaflavones.

Technology Process of 2-Methyl-4-nitroindole

There total 7 articles about 2-Methyl-4-nitroindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 67-64-1
acetone

: 99-09-2
3-nitro-aniline

: 3484-10-4
2-methyl-4-nitro-1H-indole

Guidance literature:: With potassium tert-butylate; In dimethyl sulfoxide; at 20 ℃; for 4h;
DOI:10.1016/S0040-4039(99)01014-X

Reference yield: 65.0%

: 133053-71-1
N-(2-Methyl-3-nitro-phenyl)-acetimidic acid ethyl ester

: 3484-10-4
2-methyl-4-nitro-1H-indole

Guidance literature:: With potassium ethoxide; oxalic acid diethyl ester; In diethyl ether; for 24h; Heating;
DOI:10.1016/S0040-4039(00)88196-4