3-amino-5-(2,4-dichloro-6-ethoxyphenyl)-1-(4-methoxybenzyl)-1H-benzo[e][1,4]diazepin-2(3H)-one

Base Information

Chemical Name:3-amino-5-(2,4-dichloro-6-ethoxyphenyl)-1-(4-methoxybenzyl)-1H-benzo[e][1,4]diazepin-2(3H)-one
CAS No.:1351281-45-2
Molecular Formula:C₂₅H₂₃Cl₂N₃O₃
Molecular Weight:484.382
Hs Code.:

Synonyms:3-amino-5-(2,4-dichloro-6-ethoxyphenyl)-1-(4-methoxybenzyl)-1H-benzo[e][1,4]diazepin-2(3H)-one

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Chemical Property of 3-amino-5-(2,4-dichloro-6-ethoxyphenyl)-1-(4-methoxybenzyl)-1H-benzo[e][1,4]diazepin-2(3H)-one

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Technology Process of 3-amino-5-(2,4-dichloro-6-ethoxyphenyl)-1-(4-methoxybenzyl)-1H-benzo[e][1,4]diazepin-2(3H)-one

There total 12 articles about 3-amino-5-(2,4-dichloro-6-ethoxyphenyl)-1-(4-methoxybenzyl)-1H-benzo[e][1,4]diazepin-2(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-amino-5-(2,4-dichloro-6-ethoxyphenyl)-1-(4-methoxybenzyl)-1H-benzo[e][1,4]diazepin-2(3H)-one hydrochloride

: 1351281-45-2
3-amino-5-(2,4-dichloro-6-ethoxyphenyl)-1-(4-methoxybenzyl)-1H-benzo[e][1,4]diazepin-2(3H)-one

Guidance literature:: With sodium hydrogencarbonate; In dichloromethane;

Reference yield:

: 591-35-5
3,5-dichlorophenol

: 1351281-45-2
3-amino-5-(2,4-dichloro-6-ethoxyphenyl)-1-(4-methoxybenzyl)-1H-benzo[e][1,4]diazepin-2(3H)-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / toluene; mineral oil / 2.25 h / 0 - 10 °C / Industry scale; Inert atmosphere

1.2: 2 h / 10 °C

2.1: potassium carbonate; sodium hydroxide / N,N-dimethyl-formamide; ethanol / 50 °C / Industry scale; Inert atmosphere

2.2: 1 h / 50 - 55 °C

3.1: triethylamine / palladium diacetate; CataCXiumPOMeCy / 1,4-dioxane / 1 h / 10 °C / Inert atmosphere; Industry scale

3.2: 5 h / 80 °C / Inert atmosphere

4.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 3 h / 80 °C / Inert atmosphere

5.1: hydrogenchloride / 1,4-dioxane / 12 h / 18 - 23 °C / Industry scale; Inert atmosphere

6.1: sodium hydrogencarbonate / dichloromethane

With hydrogenchloride; sodium hydride; sodium hydrogencarbonate; sodium carbonate; potassium carbonate; triethylamine; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; CataCXiumPOMeCy; palladium diacetate; In 1,4-dioxane; 1,2-dimethoxyethane; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 16512-74-6
1-(4-methoxybenzyl)-2H-benzo[d][1,3]oxazine-2,4(1H)-dione

: 1351281-45-2
3-amino-5-(2,4-dichloro-6-ethoxyphenyl)-1-(4-methoxybenzyl)-1H-benzo[e][1,4]diazepin-2(3H)-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: acetic acid / 24 h / 92 °C / Industry scale; Inert atmosphere

2.1: N,N-dimethyl-aniline; phosphorus trichloride / toluene / 16 h / 110 °C / Industry scale; Inert atmosphere

2.2: 25 °C / pH > 12

3.1: 2,4,6-Triisopropylbenzenesulfonyl azide; potassium tert-butylate / 2-methyltetrahydrofuran / 2.5 h / 40 - 50 °C / Inert atmosphere; 3 ? molecular sieve

3.2: 36 h / -20 - 30 °C / pH > 12

4.1: hydrogen / platinum(IV) oxide / 1,4-dioxane / 3 h / 7500.75 Torr / Industry scale; Autoclave

5.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 3 h / 80 °C / Inert atmosphere

6.1: hydrogenchloride / 1,4-dioxane / 12 h / 18 - 23 °C / Industry scale; Inert atmosphere

7.1: sodium hydrogencarbonate / dichloromethane

With hydrogenchloride; 2,4,6-Triisopropylbenzenesulfonyl azide; potassium tert-butylate; hydrogen; sodium hydrogencarbonate; sodium carbonate; acetic acid; N,N-dimethyl-aniline; phosphorus trichloride; platinum(IV) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 2-methyltetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; toluene;