(S)-3-amino-5-(2,4-dichloro-6-ethoxyphenyl)-1-(4-methoxybenzyl)-1H-benzo[e][1,4]diazepin-2(3H)-one

Base Information

Chemical Name:(S)-3-amino-5-(2,4-dichloro-6-ethoxyphenyl)-1-(4-methoxybenzyl)-1H-benzo[e][1,4]diazepin-2(3H)-one
CAS No.:1351281-46-3
Molecular Formula:C₂₅H₂₃Cl₂N₃O₃
Molecular Weight:484.382
Hs Code.:

Synonyms:(S)-3-amino-5-(2,4-dichloro-6-ethoxyphenyl)-1-(4-methoxybenzyl)-1H-benzo[e][1,4]diazepin-2(3H)-one

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Chemical Property of (S)-3-amino-5-(2,4-dichloro-6-ethoxyphenyl)-1-(4-methoxybenzyl)-1H-benzo[e][1,4]diazepin-2(3H)-one

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Technology Process of (S)-3-amino-5-(2,4-dichloro-6-ethoxyphenyl)-1-(4-methoxybenzyl)-1H-benzo[e][1,4]diazepin-2(3H)-one

There total 16 articles about (S)-3-amino-5-(2,4-dichloro-6-ethoxyphenyl)-1-(4-methoxybenzyl)-1H-benzo[e][1,4]diazepin-2(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 3-amino-5-(2,4-dichloro-6-ethoxyphenyl)-1-(4-methoxybenzyl)-1H-benzo[e][1,4]diazepin-2(3H)-one hydrochloride

: 1351281-46-3
(S)-3-amino-5-(2,4-dichloro-6-ethoxyphenyl)-1-(4-methoxybenzyl)-1H-benzo[e][1,4]diazepin-2(3H)-one

Guidance literature:: With (2R,3R)-2,3-bis(benzyloxy)tartaric acid; sodium hydrogencarbonate; 3,5-dichlorosalicyclaldehyde; In dichloromethane; Isopropyl acetate; water; at 70 ℃; for 3h;

Reference yield:

: 1351281-45-2
3-amino-5-(2,4-dichloro-6-ethoxyphenyl)-1-(4-methoxybenzyl)-1H-benzo[e][1,4]diazepin-2(3H)-one

: 1351281-46-3
(S)-3-amino-5-(2,4-dichloro-6-ethoxyphenyl)-1-(4-methoxybenzyl)-1H-benzo[e][1,4]diazepin-2(3H)-one

Guidance literature:: With O,O'-dibenzoyl-L-tartaric acid; 3,5-dichlorosalicyclaldehyde; In Isopropyl acetate; at 20 - 70 ℃; for 3h;

Reference yield:

: 118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4
anthranilic acid

: 1351281-46-3
(S)-3-amino-5-(2,4-dichloro-6-ethoxyphenyl)-1-(4-methoxybenzyl)-1H-benzo[e][1,4]diazepin-2(3H)-one

Guidance literature:: Multi-step reaction with 9 steps

1.1: acetic acid / dichloromethane / 0.5 h / 40 °C / Inert atmosphere

1.2: 16 h / 20 °C

2.1: tetrahydrofuran / 16 h / 15 - 20 °C / Inert atmosphere

3.1: acetic acid / 27 h / 92 °C / Inert atmosphere

4.1: trichlorophosphate / toluene; N,N-dimethyl-aniline / 16 h / 110 °C / Inert atmosphere

4.2: 25 °C / pH 12

5.1: 2,4,6-Triisopropylbenzenesulfonyl azide; potassium tert-butylate / 2-methyltetrahydrofuran / 3.5 h / -50 - -40 °C / Inert atmosphere; 3 ? Molecular sieve

5.2: 36 h / -20 - 30 °C

5.3: pH 8

6.1: hydrogen / platinum(IV) oxide / 1,4-dioxane / 3 h / 7500.75 Torr / Autoclave

7.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 3.75 h / 80 °C / Inert atmosphere

8.1: hydrogenchloride / 1,4-dioxane / 12 h / 18 - 23 °C / Inert atmosphere

9.1: sodium hydrogencarbonate; 3,5-dichlorosalicyclaldehyde; (2R,3R)-2,3-bis(benzyloxy)tartaric acid / dichloromethane; water; Isopropyl acetate / 3 h / 70 °C

With hydrogenchloride; 2,4,6-Triisopropylbenzenesulfonyl azide; potassium tert-butylate; (2R,3R)-2,3-bis(benzyloxy)tartaric acid; hydrogen; sodium hydrogencarbonate; sodium carbonate; acetic acid; trichlorophosphate; 3,5-dichlorosalicyclaldehyde; platinum(IV) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 2-methyltetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; Isopropyl acetate; water; acetic acid; N,N-dimethyl-aniline; toluene;