(2S,3R)-2-(2-Benzyloxy-ethyl)-3-(tert-butyl-dimethyl-silanyloxy)-butyramide

Base Information

Chemical Name:(2S,3R)-2-(2-Benzyloxy-ethyl)-3-(tert-butyl-dimethyl-silanyloxy)-butyramide
CAS No.:141355-53-5
Molecular Formula:C₁₉H₃₃NO₃Si
Molecular Weight:351.561
Hs Code.:

Synonyms:(2S,3R)-2-(2-Benzyloxy-ethyl)-3-(tert-butyl-dimethyl-silanyloxy)-butyramide

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Chemical Property of (2S,3R)-2-(2-Benzyloxy-ethyl)-3-(tert-butyl-dimethyl-silanyloxy)-butyramide

Chemical Property:

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Technology Process of (2S,3R)-2-(2-Benzyloxy-ethyl)-3-(tert-butyl-dimethyl-silanyloxy)-butyramide

There total 5 articles about (2S,3R)-2-(2-Benzyloxy-ethyl)-3-(tert-butyl-dimethyl-silanyloxy)-butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4541-14-4
4-benzyloxy-butan-1-ol

: 141355-53-5
(2S,3R)-2-(2-Benzyloxy-ethyl)-3-(tert-butyl-dimethyl-silanyloxy)-butyramide

Guidance literature:: Multi-step reaction with 5 steps

1: CrO₃, H₂SO₄ / acetone; H₂O / 0 °C

2: EtN=C=N(CH₂)3NMe₂*HCl, 4-dimethylaminopyridine / CH₂Cl₂ / Ambient temperature

3: 1.) Sn(CF₃SO₃)2, N-ethylpiperidine / 1.) CH₂Cl₂, 0 deg C, 2.) -78 deg C

4: imidazole / CH₂Cl₂ / 0 °C

5: 28percent aq. NH₃ / CH₂Cl₂ / Ambient temperature

With 1-ethyl-piperidine; 1H-imidazole; chromium(VI) oxide; dmap; ammonium hydroxide; tin(II) trifluoromethanesulfonate; sulfuric acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; water; acetone;
DOI:10.1039/c39920000436

Reference yield:

: 143091-76-3
(2S,3R)-2-(2-Benzyloxy-ethyl)-3-(tert-butyl-dimethyl-silanyloxy)-1-((R)-4-isopropyl-2-thioxo-thiazolidin-3-yl)-butan-1-one

: 141355-53-5
(2S,3R)-2-(2-Benzyloxy-ethyl)-3-(tert-butyl-dimethyl-silanyloxy)-butyramide

Guidance literature:: With ammonium hydroxide; In dichloromethane; Yield given; Ambient temperature;
DOI:10.1039/c39920000436

Reference yield:

: 10385-30-5
4-(benzyloxy)butanoic acid

: 141355-53-5
(2S,3R)-2-(2-Benzyloxy-ethyl)-3-(tert-butyl-dimethyl-silanyloxy)-butyramide

Guidance literature:: Multi-step reaction with 4 steps

1: EtN=C=N(CH₂)3NMe₂*HCl, 4-dimethylaminopyridine / CH₂Cl₂ / Ambient temperature

2: 1.) Sn(CF₃SO₃)2, N-ethylpiperidine / 1.) CH₂Cl₂, 0 deg C, 2.) -78 deg C

3: imidazole / CH₂Cl₂ / 0 °C

4: 28percent aq. NH₃ / CH₂Cl₂ / Ambient temperature

With 1-ethyl-piperidine; 1H-imidazole; dmap; ammonium hydroxide; tin(II) trifluoromethanesulfonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;
DOI:10.1039/c39920000436