143091-76-3

Basic information

• Product Name: (2S,3R)-2-(2-Benzyloxy-ethyl)-3-(tert-butyl-dimethyl-silanyloxy)-1-((R)-4-isopropyl-2-thioxo-thiazolidin-3-yl)-butan-1-one
• Synonyms: (2S,3R)-2-(2-Benzyloxy-ethyl)-3-(tert-butyl-dimethyl-silanyloxy)-1-((R)-4-isopropyl-2-thioxo-thiazolidin-3-yl)-butan-1-one
• CAS NO: 143091-76-3
• Molecular Weight: 495.823
• Mol File: 143091-76-3.mol

Chemical Properties

• CAS DataBase Reference: (2S,3R)-2-(2-Benzyloxy-ethyl)-3-(tert-butyl-dimethyl-silanyloxy)-1-((R)-4-isopropyl-2-thioxo-thiazolidin-3-yl)-butan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,3R)-2-(2-Benzyloxy-ethyl)-3-(tert-butyl-dimethyl-silanyloxy)-1-((R)-4-isopropyl-2-thioxo-thiazolidin-3-yl)-butan-1-one(143091-76-3)
• EPA Substance Registry System: (2S,3R)-2-(2-Benzyloxy-ethyl)-3-(tert-butyl-dimethyl-silanyloxy)-1-((R)-4-isopropyl-2-thioxo-thiazolidin-3-yl)-butan-1-one(143091-76-3)

Safety Data

• Hazardous Substances Data: 143091-76-3(Hazardous Substances Data)

Upstream product

• 141355-51-3 4-Benzyloxy-1-((R)-4-isopropyl-2-thioxo-thiazolidin-3-yl)-butan-1-one 
• 10385-30-5 4-(benzyloxy)butanoic acid 
• 4541-14-4 4-benzyloxy-butan-1-ol 
• 141355-52-4 (2S,3R)-2-(2-Benzyloxy-ethyl)-3-hydroxy-1-((R)-4-isopropyl-2-thioxo-thiazolidin-3-yl)-butan-1-one 
• 18162-48-6 tert-butyldimethylsilyl chloride 

Downstream Products

• 141355-53-5 (2S,3R)-2-(2-Benzyloxy-ethyl)-3-(tert-butyl-dimethyl-silanyloxy)-butyramide 

Relevant articles and documents

Convenient Asymmetric Synthesis of 3(S)-3--5-hydroxypyrrolidon-2-one, a Useful Synthon for the Thienamycin-like γ-Lactam

Chiral 3-substituted 5-hydroxypyrrolidin-2-one 12, useful for the synthesis of thienamycin-like γ-lactam, was successfully synthesised by utilising highly diastereoselective alkylation with the tin(II) enolate of 7 onto acetaldehyde, ammonolysis of the resultant amide 9, and oxidative cyclisation of 11.