benzyl (2S)-2-[3-[(2R)-2-tert-butoxycarbonylamino-3-(4-methoxyphenyl)propionylamino]-propionyloxy]-4-methylpentanoate

Base Information

• Chemical Name: benzyl (2S)-2-[3-[(2R)-2-tert-butoxycarbonylamino-3-(4-methoxyphenyl)propionylamino]-propionyloxy]-4-methylpentanoate
• CAS No.: 219606-83-4
• Molecular Formula: C₃₁H₄₂N₂O₈
• Molecular Weight: 570.683
• Mol file: 219606-83-4.mol

Synonyms:benzyl (2S)-2-[3-[(2R)-2-tert-butoxycarbonylamino-3-(4-methoxyphenyl)propionylamino]-propionyloxy]-4-methylpentanoate

Chemical Property of benzyl (2S)-2-[3-[(2R)-2-tert-butoxycarbonylamino-3-(4-methoxyphenyl)propionylamino]-propionyloxy]-4-methylpentanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl (2S)-2-[3-[(2R)-2-tert-butoxycarbonylamino-3-(4-methoxyphenyl)propionylamino]-propionyloxy]-4-methylpentanoate

There total 7 articles about benzyl (2S)-2-[3-[(2R)-2-tert-butoxycarbonylamino-3-(4-methoxyphenyl)propionylamino]-propionyloxy]-4-methylpentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N-(tert-butoxycarbonyl)-O-methyl-D-tyrosine (68856-96-2) + (S)-2-(3-Amino-propionyloxy)-4-methyl-pentanoic acid benzyl ester (245125-85-3) → benzyl (2S)-2-[3-[(2R)-2-tert-butoxycarbonylamino-3-(4-methoxyphenyl)propionylamino]-propionyloxy]-4-methylpentanoate (219606-83-4)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;

DOI:10.1016/S0040-4039(98)02014-0

Reference yield: 93.0%

N-(tert-butoxycarbonyl)-O-methyl-D-tyrosine (68856-96-2) + (2S,2'R)-benzyl 2-[(3'-{[(tert-butoxy)carbonyl]amino}propionyl)oxy]-4-methylpentanoate (219606-82-3) → benzyl (2S)-2-[3-[(2R)-2-tert-butoxycarbonylamino-3-(4-methoxyphenyl)propionylamino]-propionyloxy]-4-methylpentanoate (219606-83-4)

Guidance literature:

(2S,2'R)-benzyl 2-[(3'-{[(tert-butoxy)carbonyl]amino}propionyl)oxy]-4-methylpentanoate; With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 1h;

N-(tert-butoxycarbonyl)-O-methyl-D-tyrosine; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; dichloromethane; at 0 - 20 ℃; for 18.5h;

DOI:10.1016/j.ejmech.2014.11.068

Reference yield:

N-(tert-butoxycarbonyl)-O-methyl-D-tyrosine (68856-96-2) + (S)-2-(3-Amino-propionyloxy)-4-methyl-pentanoic acid benzyl ester; compound with trifluoro-acetic acid → benzyl (2S)-2-[3-[(2R)-2-tert-butoxycarbonylamino-3-(4-methoxyphenyl)propionylamino]-propionyloxy]-4-methylpentanoate (219606-83-4)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; dichloromethane; at 0 - 20 ℃;

DOI:10.1021/jo9907585

upstream raw materials:

N-(tert-butoxycarbonyl)-O-methyl-D-tyrosine

(S)-2-(3-Amino-propionyloxy)-4-methyl-pentanoic acid benzyl ester

benzyl (2S)-2-hydroxy-4-methylpentanoate

(2S,2'R)-benzyl 2-[(3'-{[(tert-butoxy)carbonyl]amino}propionyl)oxy]-4-methylpentanoate