N-[3-(Acetyl-benzyloxy-amino)-propyl]-2-(4-{[3-(acetyl-benzyloxy-amino)-propylcarbamoyl]-methyl}-5-oxo-[1,3]dioxolan-4-yl)-acetamide

Base Information

Chemical Name:N-[3-(Acetyl-benzyloxy-amino)-propyl]-2-(4-{[3-(acetyl-benzyloxy-amino)-propylcarbamoyl]-methyl}-5-oxo-[1,3]dioxolan-4-yl)-acetamide
CAS No.:83948-66-7
Molecular Formula:C₃₁H₄₀N₄O₉
Molecular Weight:612.68
Hs Code.:

Synonyms:N-[3-(Acetyl-benzyloxy-amino)-propyl]-2-(4-{[3-(acetyl-benzyloxy-amino)-propylcarbamoyl]-methyl}-5-oxo-[1,3]dioxolan-4-yl)-acetamide

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Chemical Property of N-[3-(Acetyl-benzyloxy-amino)-propyl]-2-(4-{[3-(acetyl-benzyloxy-amino)-propylcarbamoyl]-methyl}-5-oxo-[1,3]dioxolan-4-yl)-acetamide

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Technology Process of N-[3-(Acetyl-benzyloxy-amino)-propyl]-2-(4-{[3-(acetyl-benzyloxy-amino)-propylcarbamoyl]-methyl}-5-oxo-[1,3]dioxolan-4-yl)-acetamide

There total 6 articles about N-[3-(Acetyl-benzyloxy-amino)-propyl]-2-(4-{[3-(acetyl-benzyloxy-amino)-propylcarbamoyl]-methyl}-5-oxo-[1,3]dioxolan-4-yl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2687-43-6
O-benzylhydoxylamine hydrochloride

: 83948-66-7
N-[3-(Acetyl-benzyloxy-amino)-propyl]-2-(4-{[3-(acetyl-benzyloxy-amino)-propylcarbamoyl]-methyl}-5-oxo-[1,3]dioxolan-4-yl)-acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: 60 percent / pyridine / acetonitrile / 1.) 0 deg C, 2.) 24 h, room temperature

2: 78 percent / PPh₃, DEAD / tetrahydrofuran / 1.5 h / Ambient temperature

3: 65 percent / H₂ / 5percent Pd/C / ethyl acetate / 3 h / 0 °C / 760 Torr

4: 97 percent / HCl gas / diethyl ether / 0 °C

5: 90 percent Spectr_. / Et₃N / CHCl₃ / 1.) 0 deg C, 1 h, 2.) 1 h room temperature

With pyridine; hydrogenchloride; hydrogen; triethylamine; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; chloroform; ethyl acetate; acetonitrile;
DOI:10.1021/jo00149a005

Reference yield:

: 15255-86-4
N-benzyloxycarbonyl-O-benzylhydroxylamine

: 83948-66-7
N-[3-(Acetyl-benzyloxy-amino)-propyl]-2-(4-{[3-(acetyl-benzyloxy-amino)-propylcarbamoyl]-methyl}-5-oxo-[1,3]dioxolan-4-yl)-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: 78 percent / PPh₃, DEAD / tetrahydrofuran / 1.5 h / Ambient temperature

2: 65 percent / H₂ / 5percent Pd/C / ethyl acetate / 3 h / 0 °C / 760 Torr

3: 97 percent / HCl gas / diethyl ether / 0 °C

4: 90 percent Spectr_. / Et₃N / CHCl₃ / 1.) 0 deg C, 1 h, 2.) 1 h room temperature

With hydrogenchloride; hydrogen; triethylamine; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; chloroform; ethyl acetate;
DOI:10.1021/jo00149a005

Reference yield:

: 83948-52-1
O-Benzyl-N-(p-nitrobenzyloxycarbonyl)hydroxylamine

: 83948-66-7
N-[3-(Acetyl-benzyloxy-amino)-propyl]-2-(4-{[3-(acetyl-benzyloxy-amino)-propylcarbamoyl]-methyl}-5-oxo-[1,3]dioxolan-4-yl)-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: 89 percent / PPh₃, DEAD / tetrahydrofuran / 1.5 h / Ambient temperature

2: 55 percent / H₂ / 5percent Pd/C / ethyl acetate / 3 h / 0 °C / 760 Torr

3: 97 percent / HCl gas / diethyl ether / 0 °C

4: 90 percent Spectr_. / Et₃N / CHCl₃ / 1.) 0 deg C, 1 h, 2.) 1 h room temperature

With hydrogenchloride; hydrogen; triethylamine; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; chloroform; ethyl acetate;
DOI:10.1021/jo00149a005