(S)-(-)-{6-{2-[4-benzyloxy-3-bromo-5-(triisopropyl-silanyloxy)phenyl]ethylcarbamoyl}-5-[3-(4-fluoro-3-nitrophenyl)propionylamino]hexyl}carbamic acid tert-butyl ester

Base Information

Chemical Name:(S)-(-)-{6-{2-[4-benzyloxy-3-bromo-5-(triisopropyl-silanyloxy)phenyl]ethylcarbamoyl}-5-[3-(4-fluoro-3-nitrophenyl)propionylamino]hexyl}carbamic acid tert-butyl ester
CAS No.:907602-61-3
Molecular Formula:C₄₅H₆₄BrFN₄O₈Si
Molecular Weight:916.013
Hs Code.:

(S)-(-)-{6-{2-[4-benzyloxy-3-bromo-5-(triisopropyl-silanyloxy)phenyl]ethylcarbamoyl}-5-[3-(4-fluoro-3-nitrophenyl)propionylamino]hexyl}carbamic acid tert-butyl ester

Synonyms:(S)-(-)-{6-{2-[4-benzyloxy-3-bromo-5-(triisopropyl-silanyloxy)phenyl]ethylcarbamoyl}-5-[3-(4-fluoro-3-nitrophenyl)propionylamino]hexyl}carbamic acid tert-butyl ester

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Chemical Property of (S)-(-)-{6-{2-[4-benzyloxy-3-bromo-5-(triisopropyl-silanyloxy)phenyl]ethylcarbamoyl}-5-[3-(4-fluoro-3-nitrophenyl)propionylamino]hexyl}carbamic acid tert-butyl ester

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Technology Process of (S)-(-)-{6-{2-[4-benzyloxy-3-bromo-5-(triisopropyl-silanyloxy)phenyl]ethylcarbamoyl}-5-[3-(4-fluoro-3-nitrophenyl)propionylamino]hexyl}carbamic acid tert-butyl ester

There total 11 articles about (S)-(-)-{6-{2-[4-benzyloxy-3-bromo-5-(triisopropyl-silanyloxy)phenyl]ethylcarbamoyl}-5-[3-(4-fluoro-3-nitrophenyl)propionylamino]hexyl}carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 907602-60-2
{5-amino-6-[2-(4-benzyloxy-3-bromo-5-triisopropylsilanyloxy-phenyl)-ethylcarbamoyl]-hexyl}-carbamic acid tert-butyl ester

: 160877-40-7
3-(4-fluoro-3-nitrophenyl)propionic acid

: 907602-61-3
(S)-(-)-{6-{2-[4-benzyloxy-3-bromo-5-(triisopropyl-silanyloxy)phenyl]ethylcarbamoyl}-5-[3-(4-fluoro-3-nitrophenyl)propionylamino]hexyl}carbamic acid tert-butyl ester

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 6h;
DOI:10.1021/jm050708u

Reference yield:

: 907602-44-2
3-(4-fluoro-3-nitrophenyl)propionic acid methyl ester

: 907602-61-3
(S)-(-)-{6-{2-[4-benzyloxy-3-bromo-5-(triisopropyl-silanyloxy)phenyl]ethylcarbamoyl}-5-[3-(4-fluoro-3-nitrophenyl)propionylamino]hexyl}carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / LiOH / tetrahydrofuran; methanol; H₂O

2: 60 mg / HOBt; EDCI / CH₂Cl₂ / 6 h / 20 °C

With lithium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/jm050708u

Reference yield:

: 907602-39-5
5-(2-aminoethyl)-2-benzyloxy-3-bromophenol

: 907602-61-3
(S)-(-)-{6-{2-[4-benzyloxy-3-bromo-5-(triisopropyl-silanyloxy)phenyl]ethylcarbamoyl}-5-[3-(4-fluoro-3-nitrophenyl)propionylamino]hexyl}carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: acetonitrile / 3 h

1.2: 76 percent / Na₂CO₃ / methanol; H₂O / 12 h / 20 °C

2.1: 95 percent / imidazole / dimethylformamide / 20 °C

3.1: 95 percent / CF₃CO₂H / CH₂Cl₂ / 0.5 h / 0 °C

4.1: 81 percent / HOBt; EDCI / CH₂Cl₂ / 3 h / 20 °C

5.1: tris(2-aminoethyl)amine / CH₂Cl₂ / 0.08 h / 20 °C

6.1: 60 mg / HOBt; EDCI / CH₂Cl₂ / 6 h / 20 °C

With 1H-imidazole; 2,2',2''-triaminotriethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm050708u