160877-40-7Relevant articles and documents
Benzylbenzimidazolyl derivatives
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, (2008/06/13)
Novel benzyl-benzimidazolyl derivatives as inhibitors of tyrosine kinases, particularly TIE-2, VEGFR, PDGFR, FGFR and/or FLT/KDR, for the treatment of tumors, according to formula (I), wherein the radicals R1, R2, r and s are defined according to Claim (1).
BENZYL-BENZIMIDAZOLYL DERIVATIVES
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Page/Page column 53, (2010/02/11)
Novel benzyl-benzimidazolyl derivatives as inhibitors of tyrosine kinases, particularly TIE-2, VEGFR, PDGFR, FGFR and/or FLT/KDR, for the treatment of tumors, according to formula (I), wherein the radicals R1, R2, r and s are defined according to Claim (1).
SNAr-Based Macrocyclization: An Application to the Synthesis of Vancomycin Family Models
Beugelmans, Rene,Singh, Girij Pal,Bois-Choussy, Michele,Chastanet, Jacqueline,Zhu, Jieping
, p. 5535 - 5542 (2007/10/02)
The first examples of macrocyclization using the intramolecular SNAr reaction are reported.The method has allowed the efficient preparation of the elusive 16-membered macrocyclic COD and DOE rings related to vancomycin.The mild conditions used allow the incorporation of very racemization-prone amino acids, such as p-methoxyphenylglycine, into the peptide chain.After serving as an activator, the nitro group ortho to the diaryl ether linkage is converted either into a chlorine or a hydrogen atom, thus achieving the substitution pattern found in the vancomycin family of glycopeptides.When compound 20 was submitted to the same macrocyclization conditions, two atropisomers 21 and 22 were isolated and characterized.