160877-40-7

Upstream product

• 15017-52-4 4-(bromomethyl)-1-fluoro-2-nitrobenzene 
• 105-53-3 diethyl malonate 
• 42564-51-2 4-fluoro-3-nitrobenzaldehyde 
• 20274-69-5 (4-fluoro-3-nitrophenyl)methanol 
• 446-11-7 4-fluoro-3-nitrotoluene 
• 209607-59-0 (E)-methyl 3-(4-fluoro-3-nitrophenyl)acrylate 
• 907602-44-2 3-(4-fluoro-3-nitrophenyl)propionic acid methyl ester 
• 160877-38-3 diethyl 2-(4'-fluoro-3'-nitrophenyl)methylmalonate 
• 459-57-4 4-fluorobenzaldehyde 

Downstream Products

• 203310-99-0 (2S)-methyl 3-(3,4-dihydroxyphenyl)-2-[3-(4-fluoro-3-nitrophenyl)propionylamino]propionate 
• 221123-56-4 2-[3-(4-fluoro-3-nitrophenyl)propyl]-5-(3-isopropoxy-4-methoxyphenyl)-3-oxopentanoic acid ethyl ester 
• 221123-57-5 7-(4-fluoro-3-nitrophenyl)-1-(3-isopropoxy-4-methoxyphenyl)heptan-3-one 
• 221123-58-6 7-(4-fluoro-3-nitrophenyl)-1-(3-hydroxy-4-methoxyphenyl)heptan-3-one 
• 221123-67-7 3-(4-fluoro-3-nitrophenyl)propyl iodide 
• 907602-62-4 (S)-(-)-[4-(4-benzyloxy-5-bromo-20-nitro-11,15-dioxo-2-oxa-10,14-diaza-tricyclo[16.2.2.1^3,7]tricosa-1⁽²¹⁾,3⁽²³⁾,4,6,18⁽²²⁾,19-hexaen-13-yl)butyl]carbamic acid tert-butyl ester 
• 907602-63-5 (S)-[4-(20-amino-4-benzyloxy-5-bromo-11,15-dioxo-2-oxa-10,14-diaza-tricyclo[16.2.2.1^3,7]tricosa-1⁽²¹⁾,3⁽²³⁾,4,6,18⁽²²⁾,19-hexaen-13-yl)butyl]carbamic acid tert-butyl ester 
• 907602-55-5 4-benzyloxy-5-bromo-20-nitro-2-oxa-10,14-diaza-tricyclo[16.2.2.1^3,7]tricosa-1⁽²¹⁾,3⁽²³⁾,4,6,18⁽²²⁾,19-hexaene-11,15-dione 
• 907602-56-6 20-amino-4-benzyloxy-5-bromo-2-oxa-10,14-diaza-tricyclo[16.2.2.1^3,7]tricosa-1⁽²¹⁾,3⁽²³⁾,4,6,18⁽²²⁾,19-hexaene-11,15-dione 
• 907602-57-7 4-benzyloxy-5,20-dibromo-2-oxa-10,14-diaza-tricyclo[16.2.2.1^3,7]tricosa-1⁽²¹⁾,3⁽²³⁾,4,6,18⁽²²⁾,19-hexaene-11,15-dione 
• 907602-45-3 4-benzyloxy-5-bromo-16-nitro-2-oxa-10-aza-tricyclo[12.2.2.1^3,7]-nonadeca-1⁽¹⁷⁾,3⁽¹⁹⁾,4,6,14⁽¹⁸⁾,15-hexaen-11-one 
• 907602-47-5 5,16-dibromo-4-benzyloxy-2-oxa-10-aza-tricyclo[12.2.2.1^3,7]-nonadeca-1⁽¹⁷⁾,3⁽¹⁹⁾,4,6,14⁽¹⁸⁾,15-hexaen-11-one 
• 907602-46-4 16-amino-4-benzyloxy-5-bromo-2-oxa-10-aza-tricyclo[12.2.2.1^3,7]-nonadeca-1⁽¹⁷⁾,3⁽¹⁹⁾,4,6,14⁽¹⁸⁾,15-hexaen-11-one 
• 907602-49-7 4-benzyloxy-5-bromo-2-oxa-10-aza-tricyclo[12.2.2.1^3,7]-nonadeca-1⁽¹⁷⁾,3⁽¹⁹⁾,4,6,14⁽¹⁸⁾,15-hexaen-11-one 

Relevant academic research and scientific papers

Benzylbenzimidazolyl derivatives

Novel benzyl-benzimidazolyl derivatives as inhibitors of tyrosine kinases, particularly TIE-2, VEGFR, PDGFR, FGFR and/or FLT/KDR, for the treatment of tumors, according to formula (I), wherein the radicals R1, R2, r and s are defined according to Claim (1).

Simplified cyclic analogues of bastadin-5. Structure-activity relationships for modulation of the RyR1/FKBP12 Ca2+ channel complex

Bastadin-5, a brominated macrodilactam from the marine sponge Ianthella basta, enhances release of Ca2+ from stores within the sarcoplasmic reticulum (SR) of muscle and nonmuscle cells by modulating RyR1/FKBP12 complex. Analogues of bastadin-5

BENZYL-BENZIMIDAZOLYL DERIVATIVES

Novel benzyl-benzimidazolyl derivatives as inhibitors of tyrosine kinases, particularly TIE-2, VEGFR, PDGFR, FGFR and/or FLT/KDR, for the treatment of tumors, according to formula (I), wherein the radicals R1, R2, r and s are defined according to Claim (1).

A unified strategy toward the synthesis of acerogenin-type macrocycles: Total syntheses of acerogenins A, B, C, and L and aceroside IV

A general strategy for the synthesis of acerogenin-type diarylheptanoids containing an endocyclic biaryl ether bond has been developed, and convergent total syntheses of acerogenin A, B, C, and L and aceroside IV have been accomplished. Cycloetherificatio

SNAr-Based Macrocyclization: An Application to the Synthesis of Vancomycin Family Models

The first examples of macrocyclization using the intramolecular SNAr reaction are reported.The method has allowed the efficient preparation of the elusive 16-membered macrocyclic COD and DOE rings related to vancomycin.The mild conditions used allow the incorporation of very racemization-prone amino acids, such as p-methoxyphenylglycine, into the peptide chain.After serving as an activator, the nitro group ortho to the diaryl ether linkage is converted either into a chlorine or a hydrogen atom, thus achieving the substitution pattern found in the vancomycin family of glycopeptides.When compound 20 was submitted to the same macrocyclization conditions, two atropisomers 21 and 22 were isolated and characterized.