Technology Process of 6,4',5'-Trimethoxy-2'-((4S,9aR)-2-oxo-octahydro-quinolizin-4-yl)-biphenyl-3-carbonitrile
There total 5 articles about 6,4',5'-Trimethoxy-2'-((4S,9aR)-2-oxo-octahydro-quinolizin-4-yl)-biphenyl-3-carbonitrile which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: K2CO3 / acetone
2: 30 percent / naphthalene / Cu bronze / 2 h / 220 °C
3: 1.) aq. NaOH / 1.) THF, MeOH room temp. 48 h; 2.) MeOH, reflux, 4 h
With
sodium hydroxide; naphthalene; potassium carbonate;
copper bronze;
In
acetone;
DOI:10.1016/S0040-4039(00)87127-0
- Guidance literature:
-
Multi-step reaction with 4 steps
1: I2, aq. NaHCO3
2: K2CO3 / acetone
3: 30 percent / naphthalene / Cu bronze / 2 h / 220 °C
4: 1.) aq. NaOH / 1.) THF, MeOH room temp. 48 h; 2.) MeOH, reflux, 4 h
With
sodium hydroxide; naphthalene; iodine; sodium hydrogencarbonate; potassium carbonate;
copper bronze;
In
acetone;
DOI:10.1016/S0040-4039(00)87127-0
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 30 percent / naphthalene / Cu bronze / 2 h / 220 °C
2: 1.) aq. NaOH / 1.) THF, MeOH room temp. 48 h; 2.) MeOH, reflux, 4 h
With
sodium hydroxide; naphthalene;
copper bronze;
DOI:10.1016/S0040-4039(00)87127-0
