2'-((2R,4S,9aR)-2-Hydroxy-octahydro-quinolizin-4-yl)-6,4',5'-trimethoxy-biphenyl-3-carbaldehyde

Base Information

Chemical Name:2'-((2R,4S,9aR)-2-Hydroxy-octahydro-quinolizin-4-yl)-6,4',5'-trimethoxy-biphenyl-3-carbaldehyde
CAS No.:82504-09-4
Molecular Formula:C₂₅H₃₁NO₅
Molecular Weight:425.525
Hs Code.:

Synonyms:2'-((2R,4S,9aR)-2-Hydroxy-octahydro-quinolizin-4-yl)-6,4',5'-trimethoxy-biphenyl-3-carbaldehyde

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Chemical Property of 2'-((2R,4S,9aR)-2-Hydroxy-octahydro-quinolizin-4-yl)-6,4',5'-trimethoxy-biphenyl-3-carbaldehyde

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Technology Process of 2'-((2R,4S,9aR)-2-Hydroxy-octahydro-quinolizin-4-yl)-6,4',5'-trimethoxy-biphenyl-3-carbaldehyde

There total 6 articles about 2'-((2R,4S,9aR)-2-Hydroxy-octahydro-quinolizin-4-yl)-6,4',5'-trimethoxy-biphenyl-3-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 82504-08-3
6,4',5'-Trimethoxy-2'-((4S,9aR)-2-oxo-octahydro-quinolizin-4-yl)-biphenyl-3-carbonitrile

: 82504-09-4
2'-((2R,4S,9aR)-2-Hydroxy-octahydro-quinolizin-4-yl)-6,4',5'-trimethoxy-biphenyl-3-carbaldehyde

Guidance literature:: With L-Selectride; In tetrahydrofuran; at -78 - 20 ℃; for 12h;
DOI:10.1016/S0040-4039(00)87127-0

Reference yield:

: 5392-10-9
2-bromo-4,5-dimethoxybenzaldehyde

: 82504-09-4
2'-((2R,4S,9aR)-2-Hydroxy-octahydro-quinolizin-4-yl)-6,4',5'-trimethoxy-biphenyl-3-carbaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: 30 percent / naphthalene / Cu bronze / 2 h / 220 °C

2: 1.) aq. NaOH / 1.) THF, MeOH room temp. 48 h; 2.) MeOH, reflux, 4 h

3: 93 percent / lithium tri-sec-butylborohydride / tetrahydrofuran / 12 h / -78 - 20 °C

With sodium hydroxide; naphthalene; L-Selectride; copper bronze; In tetrahydrofuran;
DOI:10.1016/S0040-4039(00)87127-0

Reference yield:

: 2296-23-3
2-iodo-4-cyanophenol

: 82504-09-4
2'-((2R,4S,9aR)-2-Hydroxy-octahydro-quinolizin-4-yl)-6,4',5'-trimethoxy-biphenyl-3-carbaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: K₂CO₃ / acetone

2: 30 percent / naphthalene / Cu bronze / 2 h / 220 °C

3: 1.) aq. NaOH / 1.) THF, MeOH room temp. 48 h; 2.) MeOH, reflux, 4 h

4: 93 percent / lithium tri-sec-butylborohydride / tetrahydrofuran / 12 h / -78 - 20 °C

With sodium hydroxide; naphthalene; L-Selectride; potassium carbonate; copper bronze; In tetrahydrofuran; acetone;
DOI:10.1016/S0040-4039(00)87127-0