N-[(2-chloro-4-fluorophenyl)methyl]-2-{1-[6-(ethyloxy)-2-pyridinyl]-1H-pyrazol-4-yl}acetamide

Base Information

Chemical Name:N-[(2-chloro-4-fluorophenyl)methyl]-2-{1-[6-(ethyloxy)-2-pyridinyl]-1H-pyrazol-4-yl}acetamide
CAS No.:1082827-09-5
Molecular Formula:C₁₉H₁₈ClFN₄O₂
Molecular Weight:388.829
Hs Code.:

Synonyms:N-[(2-chloro-4-fluorophenyl)methyl]-2-{1-[6-(ethyloxy)-2-pyridinyl]-1H-pyrazol-4-yl}acetamide

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Chemical Property of N-[(2-chloro-4-fluorophenyl)methyl]-2-{1-[6-(ethyloxy)-2-pyridinyl]-1H-pyrazol-4-yl}acetamide

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Technology Process of N-[(2-chloro-4-fluorophenyl)methyl]-2-{1-[6-(ethyloxy)-2-pyridinyl]-1H-pyrazol-4-yl}acetamide

There total 4 articles about N-[(2-chloro-4-fluorophenyl)methyl]-2-{1-[6-(ethyloxy)-2-pyridinyl]-1H-pyrazol-4-yl}acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4645-11-8
6-ethoxy-2-bromo-pyridine

: 1082827-96-0
N-[(2-chloro-4-fluorophenyl)methyl]-2-(1H-pyrazol-4-yl)acetamide

: 1082827-09-5
N-[(2-chloro-4-fluorophenyl)methyl]-2-{1-[6-(ethyloxy)-2-pyridinyl]-1H-pyrazol-4-yl}acetamide

Guidance literature:: With copper(l) iodide; potassium carbonate; N,N`-dimethylethylenediamine; In 1-methyl-pyrrolidin-2-one; at 180 ℃; for 1h; Microwave irradiation;

Reference yield:

: 1082828-00-9
N-[(2-chloro-4-fluorophenyl)methyl]-2-[1-(triphenylmethyl)-1H-pyrazol-4-yl]acetamide

: 1082827-09-5
N-[(2-chloro-4-fluorophenyl)methyl]-2-{1-[6-(ethyloxy)-2-pyridinyl]-1H-pyrazol-4-yl}acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 18 h / 20 °C

2: copper(l) iodide; potassium carbonate; N,N`-dimethylethylenediamine / 1-methyl-pyrrolidin-2-one / 1 h / 180 °C / Microwave irradiation

With copper(l) iodide; potassium carbonate; trifluoroacetic acid; N,N`-dimethylethylenediamine; In 1-methyl-pyrrolidin-2-one; dichloromethane;

Reference yield:

: 163009-06-1
[1-(triphenylmethyl)-1H-pyrazol-4-yl]acetic acid

: 1082827-09-5
N-[(2-chloro-4-fluorophenyl)methyl]-2-{1-[6-(ethyloxy)-2-pyridinyl]-1H-pyrazol-4-yl}acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethylmorpholine;; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 18 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 18 h / 20 °C

3: copper(l) iodide; potassium carbonate; N,N`-dimethylethylenediamine / 1-methyl-pyrrolidin-2-one / 1 h / 180 °C / Microwave irradiation

With N-ethylmorpholine;; copper(l) iodide; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; N,N`-dimethylethylenediamine; In 1-methyl-pyrrolidin-2-one; dichloromethane;