4-(4-tert-butoxy-benzyl)-5-oxo-4-(2-oxo-ethyl)-oxazolidine-3-carboxylic acid benzyl ester

Base Information

• Chemical Name: 4-(4-tert-butoxy-benzyl)-5-oxo-4-(2-oxo-ethyl)-oxazolidine-3-carboxylic acid benzyl ester
• CAS No.: 1027054-48-3
• Molecular Formula: C₂₄H₂₇NO₆
• Molecular Weight: 425.481

Synonyms:4-(4-tert-butoxy-benzyl)-5-oxo-4-(2-oxo-ethyl)-oxazolidine-3-carboxylic acid benzyl ester

Chemical Property of 4-(4-tert-butoxy-benzyl)-5-oxo-4-(2-oxo-ethyl)-oxazolidine-3-carboxylic acid benzyl ester

Chemical Property:

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Technology Process of 4-(4-tert-butoxy-benzyl)-5-oxo-4-(2-oxo-ethyl)-oxazolidine-3-carboxylic acid benzyl ester

There total 3 articles about 4-(4-tert-butoxy-benzyl)-5-oxo-4-(2-oxo-ethyl)-oxazolidine-3-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4R,S)-3-(benzyloxycarbonyl)-4-(4-tert-butoxyphenylmethyl)-4-[1-(2-propenyl)]-1,3-oxazolidin-5-one (802912-25-0) → 4-(4-tert-butoxy-benzyl)-5-oxo-4-(2-oxo-ethyl)-oxazolidine-3-carboxylic acid benzyl ester (1027054-48-3)

Guidance literature:

With sodium periodate; osmium(VIII) oxide; In 1,4-dioxane; at 20 ℃; for 22h;

DOI:10.1021/jm049651m

Reference yield:

N-(benzyloxycarbonyl)-O-(1,1-dimethylethyl)-L-tyrosine (5545-54-0) → 4-(4-tert-butoxy-benzyl)-5-oxo-4-(2-oxo-ethyl)-oxazolidine-3-carboxylic acid benzyl ester (1027054-48-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 38 percent / benzene / 24 h / Heating

2.1: potassium hexamethyldisilylamide / tetrahydrofuran; toluene / -78 - -70 °C

2.2: 65 percent / tetrahydrofuran; toluene / 15 h / -70 °C

3.1: OsO₄; aq. NaIO₄ / dioxane / 22 h / 20 °C

With sodium periodate; osmium(VIII) oxide; potassium hexamethylsilazane; In tetrahydrofuran; 1,4-dioxane; toluene; benzene;

DOI:10.1021/jm049651m

Reference yield:

(4S)-3-(benzyloxycarbonyl)-4-(4-tert-butoxyphenylmethyl)-1,3-oxazolidin-5-one (802912-24-9) → 4-(4-tert-butoxy-benzyl)-5-oxo-4-(2-oxo-ethyl)-oxazolidine-3-carboxylic acid benzyl ester (1027054-48-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium hexamethyldisilylamide / tetrahydrofuran; toluene / -78 - -70 °C

1.2: 65 percent / tetrahydrofuran; toluene / 15 h / -70 °C

2.1: OsO₄; aq. NaIO₄ / dioxane / 22 h / 20 °C

With sodium periodate; osmium(VIII) oxide; potassium hexamethylsilazane; In tetrahydrofuran; 1,4-dioxane; toluene;

DOI:10.1021/jm049651m

upstream raw materials:

(4R,S)-3-(benzyloxycarbonyl)-4-(4-tert-butoxyphenylmethyl)-4-[1-(2-propenyl)]-1,3-oxazolidin-5-one

N-(benzyloxycarbonyl)-O-(1,1-dimethylethyl)-L-tyrosine

(4S)-3-(benzyloxycarbonyl)-4-(4-tert-butoxyphenylmethyl)-1,3-oxazolidin-5-one

Downstream raw materials:

(4R,S)-3-(benzyloxycarbonyl)-4-(4-tert-butoxyphenylmethyl)-4-(2,2-dimethoxyethyl)-1,3-oxazolidin-5-one

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