Technology Process of 3-bromo-4-(2-thiophen-3-ylethoxy)benzonitrile
There total 1 articles about 3-bromo-4-(2-thiophen-3-ylethoxy)benzonitrile which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran;
at 0 - 20 ℃;
DOI:10.1021/jm2007084
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: palladium diacetate; potassium carbonate; triphenylphosphine / N,N-dimethyl-formamide / 16 h / 90 °C
2.1: N-Bromosuccinimide; acetic acid / dichloromethane / 16 h / 20 °C
3.1: n-butyllithium / tetrahydrofuran / 1 h / -78 - -10 °C
3.2: 4.25 h / -78 - 20 °C
4.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 0.5 h / 20 °C
5.1: potassium carbonate / acetonitrile / 16 h / 20 °C
6.1: dihydrogen peroxide; potassium carbonate / water; dimethyl sulfoxide / 20 °C
With
N-Bromosuccinimide; n-butyllithium; oxalyl dichloride; dihydrogen peroxide; palladium diacetate; potassium carbonate; acetic acid; triphenylphosphine;
In
tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm2007084
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: palladium diacetate; potassium carbonate; triphenylphosphine / N,N-dimethyl-formamide / 16 h / 90 °C
2.1: N-Bromosuccinimide; acetic acid / dichloromethane / 16 h / 20 °C
3.1: n-butyllithium / tetrahydrofuran / 1 h / -78 - -10 °C
3.2: 4.25 h / -78 - 20 °C
4.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 0.5 h / 20 °C
5.1: potassium carbonate / acetonitrile / 16 h / 20 °C
6.1: dihydrogen peroxide; potassium carbonate / water; dimethyl sulfoxide / 20 °C
7.1: triethylsilane; trifluoroacetic acid / acetonitrile / 20 °C
With
triethylsilane; N-Bromosuccinimide; n-butyllithium; oxalyl dichloride; dihydrogen peroxide; palladium diacetate; potassium carbonate; acetic acid; triphenylphosphine; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm2007084