tert-butyl 4-(4-((2-fluoro-4-(methylsulfonyl)phenoxy)methyl)-2-oxocyclohexyl)piperazine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(4-((2-fluoro-4-(methylsulfonyl)phenoxy)methyl)-2-oxocyclohexyl)piperazine-1-carboxylate
CAS No.:1403676-95-8
Molecular Formula:C₂₃H₃₃FN₂O₆S
Molecular Weight:484.589
Hs Code.:

Synonyms:tert-butyl 4-(4-((2-fluoro-4-(methylsulfonyl)phenoxy)methyl)-2-oxocyclohexyl)piperazine-1-carboxylate

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Chemical Property of tert-butyl 4-(4-((2-fluoro-4-(methylsulfonyl)phenoxy)methyl)-2-oxocyclohexyl)piperazine-1-carboxylate

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Technology Process of tert-butyl 4-(4-((2-fluoro-4-(methylsulfonyl)phenoxy)methyl)-2-oxocyclohexyl)piperazine-1-carboxylate

There total 9 articles about tert-butyl 4-(4-((2-fluoro-4-(methylsulfonyl)phenoxy)methyl)-2-oxocyclohexyl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1403676-70-9
tert-butyl 4-(4-((2-fluoro-4-(methylsulfonyl)phenoxy)methyl)-2-hydroxycyclohexyl)piperazine-1-carboxylate

: 1403676-95-8
tert-butyl 4-(4-((2-fluoro-4-(methylsulfonyl)phenoxy)methyl)-2-oxocyclohexyl)piperazine-1-carboxylate

Guidance literature:: With pyridinium chlorochromate; In dichloromethane; at 20 ℃;

Reference yield:

: 1489-97-0
ethyl 1,4-dioxaspiro[4.5]decane-8-carboxylate

: 1403676-95-8
tert-butyl 4-(4-((2-fluoro-4-(methylsulfonyl)phenoxy)methyl)-2-oxocyclohexyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium borohydride / tetrahydrofuran / 20 h / Inert atmosphere; Reflux

1.2: 0.5 h / 0 - 20 °C

2.1: triethylamine / dichloromethane / 4.5 h / 0 - 20 °C / Inert atmosphere

3.1: caesium carbonate / N,N-dimethyl-formamide / 4 h / 100 °C / Inert atmosphere

4.1: hydrogenchloride / water; tetrahydrofuran / 42 h / 50 °C

5.1: toluene-4-sulfonic acid / toluene / 96 h / 150 °C

5.2: 3 h / 20 °C / Cooling with ice

5.3: 20 °C

6.1: sodium hydroxide; dihydrogen peroxide / tetrahydrofuran; methanol / 1 h / 20 °C

6.2: 0.25 h / 20 °C

7.1: pyridinium chlorochromate / dichloromethane / 20 °C

With hydrogenchloride; lithium borohydride; dihydrogen peroxide; caesium carbonate; triethylamine; pyridinium chlorochromate; sodium hydroxide; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 17159-79-4
ethyl 4-oxocyclohexane-1-carboxylate

: 1403676-95-8
tert-butyl 4-(4-((2-fluoro-4-(methylsulfonyl)phenoxy)methyl)-2-oxocyclohexyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: toluene-4-sulfonic acid / toluene / 18 h / Inert atmosphere; Reflux

2.1: lithium borohydride / tetrahydrofuran / 20 h / Inert atmosphere; Reflux

2.2: 0.5 h / 0 - 20 °C

3.1: triethylamine / dichloromethane / 4.5 h / 0 - 20 °C / Inert atmosphere

4.1: caesium carbonate / N,N-dimethyl-formamide / 4 h / 100 °C / Inert atmosphere

5.1: hydrogenchloride / water; tetrahydrofuran / 42 h / 50 °C

6.1: toluene-4-sulfonic acid / toluene / 96 h / 150 °C

6.2: 3 h / 20 °C / Cooling with ice

6.3: 20 °C

7.1: sodium hydroxide; dihydrogen peroxide / tetrahydrofuran; methanol / 1 h / 20 °C

7.2: 0.25 h / 20 °C

8.1: pyridinium chlorochromate / dichloromethane / 20 °C

With hydrogenchloride; lithium borohydride; dihydrogen peroxide; caesium carbonate; triethylamine; pyridinium chlorochromate; sodium hydroxide; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;