Technology Process of tert-butyl 4-(4-((2-fluoro-4-(methylsulfonyl)phenoxy)methyl)-2-hydroxycyclohexyl)piperazine-1-carboxylate
There total 8 articles about tert-butyl 4-(4-((2-fluoro-4-(methylsulfonyl)phenoxy)methyl)-2-hydroxycyclohexyl)piperazine-1-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
C23H35FN2O5S;
With
dihydrogen peroxide; sodium hydroxide;
In
tetrahydrofuran; methanol;
at 20 ℃;
for 1h;
With
hydrogenchloride;
In
methanol; water;
at 20 ℃;
for 0.25h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: lithium borohydride / tetrahydrofuran / 20 h / Inert atmosphere; Reflux
1.2: 0.5 h / 0 - 20 °C
2.1: triethylamine / dichloromethane / 4.5 h / 0 - 20 °C / Inert atmosphere
3.1: caesium carbonate / N,N-dimethyl-formamide / 4 h / 100 °C / Inert atmosphere
4.1: hydrogenchloride / water; tetrahydrofuran / 42 h / 50 °C
5.1: toluene-4-sulfonic acid / toluene / 96 h / 150 °C
5.2: 3 h / 20 °C / Cooling with ice
5.3: 20 °C
6.1: sodium hydroxide; dihydrogen peroxide / tetrahydrofuran; methanol / 1 h / 20 °C
6.2: 0.25 h / 20 °C
With
hydrogenchloride; lithium borohydride; dihydrogen peroxide; caesium carbonate; triethylamine; sodium hydroxide;
toluene-4-sulfonic acid;
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: triethylamine / dichloromethane / 4.5 h / 0 - 20 °C / Inert atmosphere
2.1: caesium carbonate / N,N-dimethyl-formamide / 4 h / 100 °C / Inert atmosphere
3.1: hydrogenchloride / water; tetrahydrofuran / 42 h / 50 °C
4.1: toluene-4-sulfonic acid / toluene / 96 h / 150 °C
4.2: 3 h / 20 °C / Cooling with ice
4.3: 20 °C
5.1: sodium hydroxide; dihydrogen peroxide / tetrahydrofuran; methanol / 1 h / 20 °C
5.2: 0.25 h / 20 °C
With
hydrogenchloride; dihydrogen peroxide; caesium carbonate; triethylamine; sodium hydroxide;
toluene-4-sulfonic acid;
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;