4-amino-5-nitro-2-phenylthiopyrimidine

Base Information

• Chemical Name: 4-amino-5-nitro-2-phenylthiopyrimidine
• CAS No.: 124732-28-1
• Molecular Formula: C₁₀H₈N₄O₂S
• Molecular Weight: 248.265
• Mol file: 124732-28-1.mol

Synonyms:4-amino-5-nitro-2-phenylthiopyrimidine

Chemical Property of 4-amino-5-nitro-2-phenylthiopyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 4-amino-5-nitro-2-phenylthiopyrimidine

There total 1 articles about 4-amino-5-nitro-2-phenylthiopyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

4-amino-2-chloro-5-nitropyrimidine (1920-66-7) + thiophenol (108-98-5) → 4-amino-5-nitro-2-phenylthiopyrimidine (124732-28-1)

Guidance literature:

With sodium ethanolate; In ethanol; for 2h; Heating;

DOI:10.1002/jhet.5570260427

Reference yield: 92.0%

4-amino-5-nitro-2-phenylthiopyrimidine (124732-28-1) → 4,5-diamino-2-phenylthiopyrimidine (124732-30-5)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 8h; under 2068.6 Torr; two portions of catalyst were added during the hydrogenation;

DOI:10.1002/jhet.5570260427

Reference yield:

4-amino-5-nitro-2-phenylthiopyrimidine (124732-28-1) → methyl 2-phenylthiopurine-8-carbamate (124732-32-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / H₂ / 5percent palladium on carbon / methanol / 8 h / 2068.6 Torr / two portions of catalyst were added during the hydrogenation

2: 62 percent / N,N'-dicyclohexylcarbodiimide / acetonitrile / 6 h / Heating

With hydrogen; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; acetonitrile;

DOI:10.1002/jhet.5570260427

upstream raw materials:

4-amino-2-chloro-5-nitropyrimidine

thiophenol

Downstream raw materials:

4,5-diamino-2-phenylthiopyrimidine

methyl 2-phenylthiopurine-8-carbamate

methyl 2-phenylsulfonylpurine-8-carbamate