4-bromobutyltrifluoromethanesulfonate

Base Information

• Chemical Name: 4-bromobutyltrifluoromethanesulfonate
• CAS No.: 103935-49-5
• Molecular Formula: C₅H₈BrF₃O₃S
• Molecular Weight: 285.082
• Mol file: 103935-49-5.mol

Synonyms:4-bromobutanol-1-trifluoromethanesulfonate

Chemical Property of 4-bromobutyltrifluoromethanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-bromobutyltrifluoromethanesulfonate

There total 4 articles about 4-bromobutyltrifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

4-Bromo-1-butanol (33036-62-3) + trifluoroacetic anhydride (407-25-0) → 4-bromobutanol-1-trifluoromethanesulfonate (103935-49-5)

Guidance literature:

With dmap; potassium carbonate; In dichloromethane; at -50 ℃; for 1h;

DOI:10.1081/SCC-120021497

Reference yield: 18.0%

1,4-dibromo-butane (110-52-1) + silver trifluoromethanesulfonate (2923-28-6) → 1,4-butanediyl trifluoromethanesulfonate (18934-34-4) + 4-chlorobutanol-1-trifluoromethanesulfonate (103935-55-3) + 4-bromobutanol-1-trifluoromethanesulfonate (103935-49-5)

Guidance literature:

In tetrachloromethane; for 7h; Title compound not separated from byproducts; Heating;

DOI:10.1021/jo00370a009

Reference yield:

trifluoromethylsulfonic anhydride (358-23-6) + 4-Bromo-1-butanol (33036-62-3) → 4-bromobutanol-1-trifluoromethanesulfonate (103935-49-5)

Guidance literature:

With pyridine; In dichloromethane; at -20 - 20 ℃;

DOI:10.3987/COM-04-10232

upstream raw materials:

1,4-dibromo-butane

silver trifluoromethanesulfonate

4-Bromo-1-butanol

trifluoroacetic anhydride

Downstream raw materials:

(3S,5S)-2,3,5,6-tetrahydro-3-(4-bromobutyl)-5-phenyl-N-(benzyloxycarbonyl)-4H-1,4-oxazine-2-one

Refernces

• 1、 -. "PRODUCTION OF COMPOUNDS COMPRISING CF30 GROUPS". Page/Page column 14. . Retrieved 2011/04/24.
• 2、 Roos, Gregory H. P.,Dastlik, Kim A.. "Highly diastereoselective alkylation of the Dellaria oxazinone template with bifunctional electrophiles". . p. 2197 - 2208. Retrieved 2007/10/03.