Base Information
- Chemical Name:CID 4328639
- CAS No.:2923-28-6
- Molecular Formula:CF3HSO3Ag
- Molecular Weight:256.939
- Hs Code.:28432900
- Mol file:2923-28-6.mol
Synonyms:SCHEMBL19713108
Synonyms:SCHEMBL19713108
99% *data from raw suppliers
Silver trifluoromethanesulfonate *data from reagent suppliers
Xi; 
C
There total 7 articles about CID 4328639 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
Reference yield: 95.0%
Reference yield: 80.0%
Reference yield:
The study focuses on the application of cationic rhodium(I) complexes with N-phosphino tert-butylsul?namides (PNSO) ligands in catalyzing [2+2+2] cycloaddition reactions. PNSO ligands, which combine sulfur chirality with phosphorous coordinating capacity, are effective in both intra- and intermolecular cycloadditions of enediynes, yielding cyclohexadiene derivatives with moderate enantiomeric excesses. The research also explores the catalyst's performance in mild conditions and short reaction times for the intermolecular cycloaddition of diynes with monoalkynes. The study concludes that PNSO ligands significantly enhance the reaction's efficiency and yield, with potential for further optimization to improve enantioselectivity, highlighting the robustness and broad applicability of the catalytic system.
The study focuses on the Au(I)-catalyzed annulation of enynes and alkynes to synthesize multiply substituted arenes, specifically styrene and fluorene products. The researchers used a variety of enynes, propargyl esters, and gold catalysts, including cationic phosphinegold(I) complexes, AuCl, and triarylphosphitegold(I) chloride, in conjunction with silver salts like AgOTf and AgSbF6 as cocatalysts. These chemicals served the purpose of selectively accessing different arene products through precise control of the reaction conditions and catalyst counterions. The study demonstrates the power of this method to prepare complex arenes from simple starting materials and provides insights into the mechanism of the reaction.
The research focuses on the gold(I)-catalyzed hydroarylation of allenes with indoles, an atom-economical approach to synthesizing functionalized arenes. The study utilizes a 1:1 mixture of a gold(I) N-heterocyclic carbene complex and AgOTf as a catalyst to facilitate the reaction at room temperature, yielding 3-allyl-indoles with modest to good efficiency. The experiments involved the reaction of variously substituted allenes with different indoles, using optimized conditions from previous studies on hydroalkoxylation and hydroamination of allenes. Reactants included monosubstituted, 1,3-disubstituted, or tetrasubstituted allenes and a range of indoles, with 1.5 equivalents of allene relative to indole typically employed. Analyses used to characterize the products and monitor the reactions included NMR spectroscopy, IR spectroscopy, gas chromatography, and HRMS, with TLC used for preliminary assessment of reaction progress. The study also explores the regioselectivity of the hydroarylation, influenced by the electronic and steric properties of the allenyl substituents, and compares the gold(I)-catalyzed allene hydroarylation mechanism to related hydroalkoxylation and hydroamination processes.
The research presents an efficient method for synthesizing 1-aminoisoquinolines, which are important components in pharmacophores and natural products, through a silver triflate and gold(I) chloride cocatalyzed reaction of 2-alkynylbenzaldoximes with isocyanoacetates. The study explores the role of gold(I) cation in activating the isocyanide substrate and provides a unique pathway for substrate activation. The experiments involved the use of various reactants, including 2-alkynylbenzaldoximes and 2-isocyanoacetates, with silver triflate and gold(I) chloride as catalysts, and triethylamine as a base, in tetrahydrofuran as the solvent at 70 °C. The analysis of the synthesized products included techniques such as infrared spectroscopy (IR), nuclear magnetic resonance (NMR), mass spectrometry (MS), and high-resolution mass spectrometry (HRMS) to confirm the structure and purity of the 1-aminoisoquinolines obtained in good to excellent yields.
The research aimed to synthesize and evaluate the antitumor properties of the 9-aza analogue of N-(trifluoroacetyl)-4-demethoxydaunomycin, a derivative of the anthracycline antibiotics doxorubicin and daunomycin. The study hypothesized that the bioisosteric replacement of carbon with nitrogen in the alicyclic A ring of the glycosides could potentially enhance antitumor activity. The synthesis involved a series of chemical reactions, including Pomeranz-Fritsch condensation, borohydride reduction, acid-catalyzed cyclization, selective N-acetylation, Friedel-Crafts acylation, epoxidation, and glycosidation with N,O-bis(trifluoroacetyl)daunosamine bromide and silver trifluoromethanesulfonate. The resulting diastereoisomers were separated and their structures confirmed using CD and NMR spectroscopy. However, the study concluded that both diastereoisomers were inactive in mice carrying the P388 tumor, suggesting that the side-chain keto moiety could not be replaced by an aliphatic amide group without losing antitumor activity. The chemicals used in the process included 2,5-dimethoxy-benzaldehyde, 2-aminoacetaldehyde dimethyl acetal, sodium borohydride, phthalic anhydride, and various reagents for protection and deprotection of functional groups, as well as for the final glycosidation step.
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