N-[4-(2-chloropyridin-4-yloxy)-2,5-difluorophenyl]-N'-[4-fluorophenyl]cyclopropane-1,1-dicarboxamide

Base Information

Chemical Name:N-[4-(2-chloropyridin-4-yloxy)-2,5-difluorophenyl]-N'-[4-fluorophenyl]cyclopropane-1,1-dicarboxamide
CAS No.:1345847-77-9
Molecular Formula:C₂₂H₁₅ClF₃N₃O₃
Molecular Weight:461.828
Hs Code.:

Synonyms:N-[4-(2-chloropyridin-4-yloxy)-2,5-difluorophenyl]-N'-[4-fluorophenyl]cyclopropane-1,1-dicarboxamide

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Chemical Property of N-[4-(2-chloropyridin-4-yloxy)-2,5-difluorophenyl]-N'-[4-fluorophenyl]cyclopropane-1,1-dicarboxamide

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Technology Process of N-[4-(2-chloropyridin-4-yloxy)-2,5-difluorophenyl]-N'-[4-fluorophenyl]cyclopropane-1,1-dicarboxamide

There total 8 articles about N-[4-(2-chloropyridin-4-yloxy)-2,5-difluorophenyl]-N'-[4-fluorophenyl]cyclopropane-1,1-dicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1-((4-fluorophenyl)carbamoyl)cyclopropane-1-carbonyl chloride

: 1225278-65-8
4-((2-chloropyridin-4-yl)oxy)-2,5-difluoroaniline

: 1345847-77-9
N-[4-(2-chloropyridin-4-yloxy)-2,5-difluorophenyl]-N'-[4-fluorophenyl]cyclopropane-1,1-dicarboxamide

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃; for 0.5h;

Reference yield:

: 2105-61-5
1,2,4-trifluoro-5-nitrobenzene

: 1345847-77-9
N-[4-(2-chloropyridin-4-yloxy)-2,5-difluorophenyl]-N'-[4-fluorophenyl]cyclopropane-1,1-dicarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.75 h / Cooling with ice; Inert atmosphere

1.2: 18 h / 20 °C

2.1: zinc; ammonium chloride / methanol / 1.5 h / 20 °C / Cooling with ice

3.1: triethylamine / tetrahydrofuran / 0.5 h / 20 °C

With sodium hydride; ammonium chloride; triethylamine; zinc; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 17368-12-6
2-chloropyridin-4-ol

: 1345847-77-9
N-[4-(2-chloropyridin-4-yloxy)-2,5-difluorophenyl]-N'-[4-fluorophenyl]cyclopropane-1,1-dicarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.75 h / Cooling with ice; Inert atmosphere

1.2: 18 h / 20 °C

2.1: zinc; ammonium chloride / methanol / 1.5 h / 20 °C / Cooling with ice

3.1: triethylamine / tetrahydrofuran / 0.5 h / 20 °C

With sodium hydride; ammonium chloride; triethylamine; zinc; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; mineral oil;