5-bromo-N₂-(3-chloro-4-fluoro-phenyl)-N₄-(3-dimethylamino-propyl)-pyrimidine-2,4-diamine

Base Information

• Chemical Name: 5-bromo-N₂-(3-chloro-4-fluoro-phenyl)-N₄-(3-dimethylamino-propyl)-pyrimidine-2,4-diamine
• CAS No.: 1220416-67-0
• Molecular Formula: C₁₅H₁₈BrClFN₅
• Molecular Weight: 402.697

Synonyms:5-bromo-N₂-(3-chloro-4-fluoro-phenyl)-N₄-(3-dimethylamino-propyl)-pyrimidine-2,4-diamine

Chemical Property of 5-bromo-N₂-(3-chloro-4-fluoro-phenyl)-N₄-(3-dimethylamino-propyl)-pyrimidine-2,4-diamine

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Technology Process of 5-bromo-N₂-(3-chloro-4-fluoro-phenyl)-N₄-(3-dimethylamino-propyl)-pyrimidine-2,4-diamine

There total 1 articles about 5-bromo-N₂-(3-chloro-4-fluoro-phenyl)-N₄-(3-dimethylamino-propyl)-pyrimidine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

3-chloro-4-fluorophenylamine (367-21-5) + N'-(5-bromo-2-chloro-pyrimidin-4-yl)-N,N-dimethyl-propane-1,3-diamine (477593-55-8) → 5-bromo-N2-(3-chloro-4-fluoro-phenyl)-N4-(3-dimethylamino-propyl)-pyrimidine-2,4-diamine (1220416-67-0)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 100 ℃;

Reference yield:

5-bromo-N2-(3-chloro-4-fluoro-phenyl)-N4-(3-dimethylamino-propyl)-pyrimidine-2,4-diamine (1220416-67-0) + (2-methoxypyrimidin-5-yl)boronic acid (628692-15-9) → N2-(3-chloro-4-fluorophenyl)-N4-(3-(dimethylamino)propyl)-2'-methoxy-5,5'-bipyrimidine-2,4-diamine (1220127-41-2)

Guidance literature:

With sodium carbonate; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In water; acetonitrile; at 90 ℃; for 1h;

upstream raw materials:

3-chloro-4-fluorophenylamine

N'-(5-bromo-2-chloro-pyrimidin-4-yl)-N,N-dimethyl-propane-1,3-diamine

Downstream raw materials:

N₂-(3-chloro-4-fluorophenyl)-N₄-(3-(dimethylamino)propyl)-2'-methoxy-5,5'-bipyrimidine-2,4-diamine

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