2-[1-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-5-(2,4-difluoro-phenyl)-2-oxo-pyrrolidin-3-yl]-N-(3-chloro-2-methyl-benzyl)-acetamide

Base Information

Chemical Name:2-[1-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-5-(2,4-difluoro-phenyl)-2-oxo-pyrrolidin-3-yl]-N-(3-chloro-2-methyl-benzyl)-acetamide
CAS No.:808189-33-5
Molecular Formula:C₂₈H₃₇ClF₂N₂O₃Si
Molecular Weight:551.149
Hs Code.:

2-[1-[2-(<i>tert</i>-butyl-dimethyl-silanyloxy)-ethyl]-5-(2,4-difluoro-phenyl)-2-oxo-pyrrolidin-3-yl]-<i>N</i>-(3-chloro-2-methyl-benzyl)-acetamide

Synonyms:2-[1-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-5-(2,4-difluoro-phenyl)-2-oxo-pyrrolidin-3-yl]-N-(3-chloro-2-methyl-benzyl)-acetamide

Suppliers and Price of 2-[1-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-5-(2,4-difluoro-phenyl)-2-oxo-pyrrolidin-3-yl]-N-(3-chloro-2-methyl-benzyl)-acetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-[1-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-5-(2,4-difluoro-phenyl)-2-oxo-pyrrolidin-3-yl]-N-(3-chloro-2-methyl-benzyl)-acetamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-[1-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-5-(2,4-difluoro-phenyl)-2-oxo-pyrrolidin-3-yl]-N-(3-chloro-2-methyl-benzyl)-acetamide

There total 10 articles about 2-[1-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-5-(2,4-difluoro-phenyl)-2-oxo-pyrrolidin-3-yl]-N-(3-chloro-2-methyl-benzyl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 372-18-9
1,3-Difluorobenzene

: 808189-33-5
2-[1-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-5-(2,4-difluoro-phenyl)-2-oxo-pyrrolidin-3-yl]-N-(3-chloro-2-methyl-benzyl)-acetamide

Guidance literature:: Multi-step reaction with 12 steps

1.1: 80 percent / aluminum chloride / 0 - 80 °C

2.1: 90 percent / aq. LiOH / tetrahydrofuran

3.1: 100 percent / toluene / 16 h / Heating

4.1: 80 percent / TiCl₄; Et₃SiH / CH₂Cl₂ / 16 h / -78 - 20 °C

5.1: 95 percent / SOCl₂ / tetrahydrofuran / 0 - 20 °C

6.1: 80 percent / NaOEt / ethanol / 45 °C

7.1: 85 percent / aq. HCl / tetrahydrofuran / Heating

8.1: 75 percent / KH / dimethylformamide / 1 h / 20 °C

9.1: LDA / tetrahydrofuran / -78 °C

9.2: 70 percent / tetrahydrofuran

10.1: ozone / CH₂Cl₂ / -78 °C

10.2: 90 percent / PS-PPh₃ / CH₂Cl₂

11.1: 90 percent / KMnO₄; NaH₂PO₄ / 2-methyl-propan-2-ol

12.1: 65 percent / EDCI; HOBt / H₂O

With hydrogenchloride; triethylsilane; lithium hydroxide; potassium permanganate; sodium dihydrogenphosphate; aluminium trichloride; thionyl chloride; sodium ethanolate; titanium tetrachloride; potassium hydride; benzotriazol-1-ol; ozone; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium diisopropyl amide; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;
DOI:10.1016/j.bmcl.2004.09.001

Reference yield:

: 110931-77-6
4-(2,4-difluorophenyl)-4-oxobutanoic acid

: 808189-33-5
2-[1-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-5-(2,4-difluoro-phenyl)-2-oxo-pyrrolidin-3-yl]-N-(3-chloro-2-methyl-benzyl)-acetamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: 100 percent / toluene / 16 h / Heating

2.1: 80 percent / TiCl₄; Et₃SiH / CH₂Cl₂ / 16 h / -78 - 20 °C

3.1: 95 percent / SOCl₂ / tetrahydrofuran / 0 - 20 °C

4.1: 80 percent / NaOEt / ethanol / 45 °C

5.1: 85 percent / aq. HCl / tetrahydrofuran / Heating

6.1: 75 percent / KH / dimethylformamide / 1 h / 20 °C

7.1: LDA / tetrahydrofuran / -78 °C

7.2: 70 percent / tetrahydrofuran

8.1: ozone / CH₂Cl₂ / -78 °C

8.2: 90 percent / PS-PPh₃ / CH₂Cl₂

9.1: 90 percent / KMnO₄; NaH₂PO₄ / 2-methyl-propan-2-ol

10.1: 65 percent / EDCI; HOBt / H₂O

With hydrogenchloride; triethylsilane; potassium permanganate; sodium dihydrogenphosphate; thionyl chloride; sodium ethanolate; titanium tetrachloride; potassium hydride; benzotriazol-1-ol; ozone; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium diisopropyl amide; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;
DOI:10.1016/j.bmcl.2004.09.001

Reference yield:

: 4-(2,4-difluoro-phenyl)-4-oxo-butyryl chloride

: 808189-33-5
2-[1-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-5-(2,4-difluoro-phenyl)-2-oxo-pyrrolidin-3-yl]-N-(3-chloro-2-methyl-benzyl)-acetamide

Guidance literature:: Multi-step reaction with 11 steps

1.1: 90 percent / aq. LiOH / tetrahydrofuran

2.1: 100 percent / toluene / 16 h / Heating

3.1: 80 percent / TiCl₄; Et₃SiH / CH₂Cl₂ / 16 h / -78 - 20 °C

4.1: 95 percent / SOCl₂ / tetrahydrofuran / 0 - 20 °C

5.1: 80 percent / NaOEt / ethanol / 45 °C

6.1: 85 percent / aq. HCl / tetrahydrofuran / Heating

7.1: 75 percent / KH / dimethylformamide / 1 h / 20 °C

8.1: LDA / tetrahydrofuran / -78 °C

8.2: 70 percent / tetrahydrofuran

9.1: ozone / CH₂Cl₂ / -78 °C

9.2: 90 percent / PS-PPh₃ / CH₂Cl₂

10.1: 90 percent / KMnO₄; NaH₂PO₄ / 2-methyl-propan-2-ol

11.1: 65 percent / EDCI; HOBt / H₂O

With hydrogenchloride; triethylsilane; lithium hydroxide; potassium permanganate; sodium dihydrogenphosphate; thionyl chloride; sodium ethanolate; titanium tetrachloride; potassium hydride; benzotriazol-1-ol; ozone; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium diisopropyl amide; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;
DOI:10.1016/j.bmcl.2004.09.001