Chemical Property of Resiquimod
Chemical Property:
- Vapor Pressure:4.33E-13mmHg at 25°C
- Melting Point:190-193°
- Boiling Point:553.6°Cat760mmHg
- PKA:14.63±0.29(Predicted)
- Flash Point:288.6°C
- PSA：86.19000
- Density:1.28g/cm3
- LogP:3.05530
- Storage Temp.:?20°C
- Solubility.:DMSO: soluble10mg/mL, clear (warmed to 60 °C)
- XLogP3:1.3
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:5
- Rotatable Bond Count:5
- Exact Mass:314.17427596
- Heavy Atom Count:23
- Complexity:406
- Purity/Quality:
-
99%, *data from raw suppliers
Resiquimod *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N
- Recent ClinicalTrials:Dendritic Cell Vaccine for Patients With Brain Tumors
- Recent EU Clinical Trials:Clinical Trial Exit Interview Study in Cutaneous T-cell Lymphoma (CTCL) to Capture Meaningful Treatment Benefit from a Patient’s Perspective
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Description
Resiquimod (CAS 144875-48-9) is a Toll-like receptor 7/8 agonist.1 May be used as an immune adjuvant in cancer vaccines.2 Resiquimod-carrying synthetic vaccine particles augment the immune response to encapsulated antigen and exhibit strong local immune activation without inducing systemic cytokine release.3 Topical treatment of wild-type mice induces systemic autoimmune disease which may be used as a model of systemic Lupus erythematosus.4? It displayed potent antiviral activity (EC50 = 23.5 nM) in a murine norovirus replicon model.5
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Uses
Resiquimod is an imidazoquinoline derivative that acts as an immune response modifier. Resiquimod shows antitumor and antiviral activity and is used in the treatment of skin lesions such as herpes simplex virus. Resiquimod is a toll-like receptor 9 (TLR7) agonist. Resiquimod has been used in the stimulation of bone marrow-derived dendritic cells (BMDCs) stimulation( and B cells. It has also been used as a ligand for toll-like receptors (TLR7) in malignant melanoma cell line B16F10.
