6-(4-chloro-2-methyl-phenyl)-5-(5-chloro-2-methyl-phenyl)-2-(2,4-dimethoxy-pyrimidin-5-yl)-1-isopropyl-6-methyl-5,6-dihydro-1H-pyrrolo[3,4-d]imidazol-4-one

Base Information

Chemical Name:6-(4-chloro-2-methyl-phenyl)-5-(5-chloro-2-methyl-phenyl)-2-(2,4-dimethoxy-pyrimidin-5-yl)-1-isopropyl-6-methyl-5,6-dihydro-1H-pyrrolo[3,4-d]imidazol-4-one
CAS No.:1448867-92-2
Molecular Formula:C₂₉H₂₉Cl₂N₅O₃
Molecular Weight:566.487
Hs Code.:

6-(4-chloro-2-methyl-phenyl)-5-(5-chloro-2-methyl-phenyl)-2-(2,4-dimethoxy-pyrimidin-5-yl)-1-isopropyl-6-methyl-5,6-dihydro-1H-pyrrolo[3,4-d]imidazol-4-one

Synonyms:6-(4-chloro-2-methyl-phenyl)-5-(5-chloro-2-methyl-phenyl)-2-(2,4-dimethoxy-pyrimidin-5-yl)-1-isopropyl-6-methyl-5,6-dihydro-1H-pyrrolo[3,4-d]imidazol-4-one

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Chemical Property of 6-(4-chloro-2-methyl-phenyl)-5-(5-chloro-2-methyl-phenyl)-2-(2,4-dimethoxy-pyrimidin-5-yl)-1-isopropyl-6-methyl-5,6-dihydro-1H-pyrrolo[3,4-d]imidazol-4-one

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Technology Process of 6-(4-chloro-2-methyl-phenyl)-5-(5-chloro-2-methyl-phenyl)-2-(2,4-dimethoxy-pyrimidin-5-yl)-1-isopropyl-6-methyl-5,6-dihydro-1H-pyrrolo[3,4-d]imidazol-4-one

There total 2 articles about 6-(4-chloro-2-methyl-phenyl)-5-(5-chloro-2-methyl-phenyl)-2-(2,4-dimethoxy-pyrimidin-5-yl)-1-isopropyl-6-methyl-5,6-dihydro-1H-pyrrolo[3,4-d]imidazol-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1448867-14-8
(R)-5-(5-chloro-2-methyl-phenyl)-6-(4-chloro-2-methyl-phenyl)-2-(2,4-dimethoxy-pyrimidin-5-yl)-1-isopropyl-5,6,-dihydro-1H-pyrrolo[3,4-d]imidazol-4-one

: 74-88-4
methyl iodide

: 1448867-92-2
6-(4-chloro-2-methyl-phenyl)-5-(5-chloro-2-methyl-phenyl)-2-(2,4-dimethoxy-pyrimidin-5-yl)-1-isopropyl-6-methyl-5,6-dihydro-1H-pyrrolo[3,4-d]imidazol-4-one

Guidance literature:: (R)-5-(5-chloro-2-methyl-phenyl)-6-(4-chloro-2-methyl-phenyl)-2-(2,4-dimethoxy-pyrimidin-5-yl)-1-isopropyl-5,6,-dihydro-1H-pyrrolo[3,4-d]imidazol-4-one; With potassium hexamethylsilazane; In tetrahydrofuran; at -78 ℃; for 0.25h; Inert atmosphere;

methyl iodide; In tetrahydrofuran; at 20 ℃; for 20h; Inert atmosphere;

Reference yield:

: 1448866-44-1
5-(5-chloro-2-methyl-phenyl)-6-(4-chloro-2-methyl-phenyl)-2-(2,4-dimethoxy-pyrimidin-5-yl)-1-isopropyl-5,6,-dihydro-1H-pyrrolo[3,4-d]imidazol-4-one

: 1448867-92-2
6-(4-chloro-2-methyl-phenyl)-5-(5-chloro-2-methyl-phenyl)-2-(2,4-dimethoxy-pyrimidin-5-yl)-1-isopropyl-6-methyl-5,6-dihydro-1H-pyrrolo[3,4-d]imidazol-4-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: Chiralcel OD / ethanol; n-heptane / Resolution of racemate

2.1: potassium hexamethylsilazane / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere

2.2: 20 h / 20 °C / Inert atmosphere

With potassium hexamethylsilazane; In tetrahydrofuran; ethanol; n-heptane;