Technology Process of [4-(3-methyl-9-phenyl-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-8-yl)-benzyl]-carbamic acid tert-butyl ester
There total 10 articles about [4-(3-methyl-9-phenyl-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-8-yl)-benzyl]-carbamic acid tert-butyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
toluene-4-sulfonic acid;
In
methanol; toluene;
at 100 ℃;
for 0.583333h;
Product distribution / selectivity;
Microwave reactor;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: tetrahydrofuran; N,N-dimethyl-formamide; pentane / 5 h / -70 - 20 °C
2.1: lithium hexamethyldisilazane / tetrahydrofuran / 20 °C / Heating / reflux
3.1: hydrogenchloride; water / 1,4-dioxane / 3 h / 0 - 20 °C
3.2: pH > 7
4.1: triethylsilane; trifluoroacetic acid / acetonitrile / 3 h
5.1: hydrazine / 1,4-dioxane / 0.08 h / 100 °C / Microwave reactor
6.1: toluene-4-sulfonic acid / methanol; toluene / 0.58 h / 100 °C / Microwave reactor
With
hydrogenchloride; triethylsilane; water; toluene-4-sulfonic acid; trifluoroacetic acid; lithium hexamethyldisilazane; hydrazine;
In
tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide; toluene; acetonitrile; pentane;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 0 - 20 °C
2.1: tetrahydrofuran; N,N-dimethyl-formamide; pentane / 5 h / -70 - 20 °C
3.1: lithium hexamethyldisilazane / tetrahydrofuran / 20 °C / Heating / reflux
4.1: hydrogenchloride; water / 1,4-dioxane / 3 h / 0 - 20 °C
4.2: pH > 7
5.1: triethylsilane; trifluoroacetic acid / acetonitrile / 3 h
6.1: hydrazine / 1,4-dioxane / 0.08 h / 100 °C / Microwave reactor
7.1: toluene-4-sulfonic acid / methanol; toluene / 0.58 h / 100 °C / Microwave reactor
With
hydrogenchloride; triethylsilane; water; toluene-4-sulfonic acid; trifluoroacetic acid; lithium hexamethyldisilazane; hydrazine;
In
tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide; toluene; acetonitrile; pentane;
