4-AMINO-2-CHLOROPYRIDINE, N-BOC PROTECTED 98

Base Information

• Chemical Name: 4-AMINO-2-CHLOROPYRIDINE, N-BOC PROTECTED 98
• CAS No.: 234108-73-7
• Molecular Formula: C10H13ClN2O2
• Molecular Weight: 228.678
• Hs Code.: 2933399090
• Mol file: 234108-73-7.mol

Synonyms:Carbamicacid, (2-chloro-4-pyridinyl)-, 1,1-dimethylethyl ester (9CI);(2-Chloropyridin-4-yl)carbamic acid tert-butyl ester;tert-Butyl(2-Chloropyridin-4-yl)carbamate;tert-Butyl N-(2-chloropyridin-4-yl)carbamate;

Chemical Property of 4-AMINO-2-CHLOROPYRIDINE, N-BOC PROTECTED 98

Chemical Property:

• Vapor Pressure: 0.003mmHg at 25°C
• Melting Point: 173-175ºC
• Refractive Index: 1.557
• Boiling Point: 282.245 °C at 760 mmHg
• PKA: 11.97±0.70(Predicted)
• Flash Point: 124.498 °C
• PSA: 51.22000
• Density: 1.245 g/cm³
• LogP: 3.15500
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl(2-Chloropyridin-4-yl)carbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Uses: tert-Butyl (2-Chloropyridin-4-yl)carbamate is a reactant in the preparation of inter-domain stabilizers for allosteric Akt inhibitors.

Technology Process of 4-AMINO-2-CHLOROPYRIDINE, N-BOC PROTECTED 98

There total 3 articles about 4-AMINO-2-CHLOROPYRIDINE, N-BOC PROTECTED 98 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

4-Amino-2-chloropyridine (14432-12-3) + di-tert-butyl dicarbonate (24424-99-5) → (2-chloro-pyridin-4-yl)-carbamic acid tert-butyl ester (234108-73-7)

Guidance literature:

With triethylamine; dimethylaminopyridine; In dichloromethane; at 20 ℃;

Reference yield: 49.0%

2-chloro-4-bromopyridine (73583-37-6) + tert-butyl carbazate (4248-19-5) → (2-chloro-pyridin-4-yl)-carbamic acid tert-butyl ester (234108-73-7)

Guidance literature:

With palladium diacetate; caesium carbonate; XPhos; In 1,4-dioxane; at 100 ℃; for 24h;

DOI:10.1016/j.tetlet.2010.06.083

Reference yield:

4-Amino-2-chloropyridine (14432-12-3) + tert-butyl formate (762-75-4) → (2-chloro-pyridin-4-yl)-carbamic acid tert-butyl ester (234108-73-7)

Guidance literature:

With sodium hexamethyldisilazane; In tetrahydrofuran; at 0 - 20 ℃; for 4h;

DOI:10.1021/jm020384z

upstream raw materials:

4-Amino-2-chloropyridine

tert-butyl formate

di-tert-butyl dicarbonate

2-chloro-4-bromopyridine

Downstream raw materials:

(2-chloro-3-methylpyridin-4-yl)carbamic acid tert-butyl ester

tert-butyl (2-chloro-3-formylpyridin-4-yl)carbamate

C₁₇H₁₈ClFN₂O₂

tert-butyl (2-chloropyrid-4-yl)methylcarbamate