(2AR,4R)-1-Benzoyl-6-bromo-4-(di-n-propylamino)-1,2,2a,3,4,5-hexa-hydrobenz[cd]indole

Base Information

• Chemical Name: (2AR,4R)-1-Benzoyl-6-bromo-4-(di-n-propylamino)-1,2,2a,3,4,5-hexa-hydrobenz[cd]indole
• CAS No.: 136846-11-2
• Molecular Formula: C₂₄H₂₉BrN₂O
• Molecular Weight: 441.411
• Mol file: 136846-11-2.mol

Synonyms:(2AR,4R)-1-Benzoyl-6-bromo-4-(di-n-propylamino)-1,2,2a,3,4,5-hexa-hydrobenz[cd]indole

Chemical Property of (2AR,4R)-1-Benzoyl-6-bromo-4-(di-n-propylamino)-1,2,2a,3,4,5-hexa-hydrobenz[cd]indole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2AR,4R)-1-Benzoyl-6-bromo-4-(di-n-propylamino)-1,2,2a,3,4,5-hexa-hydrobenz[cd]indole

There total 2 articles about (2AR,4R)-1-Benzoyl-6-bromo-4-(di-n-propylamino)-1,2,2a,3,4,5-hexa-hydrobenz[cd]indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2AR,4R)-4-amino-1-benzoyl-6-bromo-1,2,2a,3,4,5-hexahydrobenz[cd]indole + potassium carbonate (584-08-7) + 1-iodo-propane (107-08-4) → (2AR,4R)-1-Benzoyl-6-bromo-4-(di-n-propylamino)-1,2,2a,3,4,5-hexa-hydrobenz[cd]indole (136846-11-2)

Guidance literature:

In ethyl acetate; acetonitrile;

Reference yield:

(2AR,4R)-4-amino-1-benzoyl-1,2,2a,3,4,5-hexahydrobenz[cd]indole → (2AR,4R)-1-Benzoyl-6-bromo-4-(di-n-propylamino)-1,2,2a,3,4,5-hexa-hydrobenz[cd]indole (136846-11-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide; bromine; sodium acetate / glacial HOAc; water; acetic acid

2: ethyl acetate; acetonitrile

With sodium hydroxide; bromine; sodium acetate; In glacial HOAc; water; acetic acid; ethyl acetate; acetonitrile;

Reference yield:

(2AR,4R)-1-Benzoyl-6-bromo-4-(di-n-propylamino)-1,2,2a,3,4,5-hexa-hydrobenz[cd]indole (136846-11-2) → (2AR,4R)-1-Benzoyl-6-cyano-4-(di-n-propylamino)-1,2,2a,3,4,5-hexahydrobenz[cd]indole

Guidance literature:

With CuI; CuCN; In ammonium hydroxide; water; ethyl acetate; N,N-dimethyl-formamide;

upstream raw materials:

potassium carbonate

1-iodo-propane

Downstream raw materials:

1-Benzoyl-6-cyano-4-(di-n-propylamino)-1,2,2a,3,4,5-hexahydrobenz[cd]indole