(3-AMINO-1-BENZOFURAN-2-YL)(4-FLUOROPHENYL)METHANONE

Base Information

• Chemical Name: (3-AMINO-1-BENZOFURAN-2-YL)(4-FLUOROPHENYL)METHANONE
• CAS No.: 128170-38-7
• Molecular Formula: C₁₅H₁₀FNO₂
• Molecular Weight: 255.248
• Mol file: 128170-38-7.mol

Synonyms:3-amino-2-(4-fluorobenzoyl)-benzo[b]furan

Chemical Property of (3-AMINO-1-BENZOFURAN-2-YL)(4-FLUOROPHENYL)METHANONE

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

2-[(4-Fluorophenyl)carbonyl]-1-benzofuran-3-amine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

Useful:

Technology Process of (3-AMINO-1-BENZOFURAN-2-YL)(4-FLUOROPHENYL)METHANONE

There total 1 articles about (3-AMINO-1-BENZOFURAN-2-YL)(4-FLUOROPHENYL)METHANONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(4-fluorophenyl)ethanone (403-42-9) → 3-amino-2-(4-fluorobenzoyl)-benzo[b]furan (128170-38-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / polymer-supported pyridinium bromide perbromide / toluene / -10 °C

2: 73 percent / polymer-supported 1,5,7-triazabicyclo[4.4.0]dec-5-ene / acetone / Heating

With 7-methyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene on polystyrene.HL; polymer-supported pyridinium bromide perbromide; In acetone; toluene; 1: Bromination / 2: Cyclization;

DOI:10.1039/a904384e

Reference yield: 76.0%

3,4,5-Trimethoxybenzoyl chloride (4521-61-3) + 3-amino-2-(4-fluorobenzoyl)-benzo[b]furan (128170-38-7) → N-(2-(4-fluorobenzoyl)-benzofuran-3-yl)-3,4,5-trimethoxybenzamide

Guidance literature:

3-amino-2-(4-fluorobenzoyl)-benzo[b]furan; With sodium t-butanolate; In dichloromethane; at 0 ℃; for 1h;

3,4,5-Trimethoxybenzoyl chloride; In dichloromethane; at 5 - 20 ℃; for 6h;

DOI:10.1016/j.bioorg.2020.104076

Reference yield:

ethyl N-(2-chloroethyl)carbamate (6329-26-6) + chloroformic acid ethyl ester (541-41-3) + 3-amino-2-(4-fluorobenzoyl)-benzo[b]furan (128170-38-7) → 5-(4-fluorophenyl)-2,3-dihydro-1H-benzofuro-[3,2-e]-1,4-diazepine (128170-34-3)

Guidance literature:

With pyridine; sodium hydroxide; ammonia; In methanol; HBr-acetic acid; ethanol; dichloromethane; N,N-dimethyl-formamide; benzene;

upstream raw materials:

1-(4-fluorophenyl)ethanone

Downstream raw materials:

5-(4-fluorophenyl)-2,3-dihydro-1H-benzofuro-[3,2-e]-1,4-diazepine